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Art. -Nr.: HY-175669

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ANO1-IN-5

ANO1-IN-5 is an orally active ANO1 inhibitor with an IC₅₀ of 4.57 μM. J ANO1-IN-5 demonstrates 118-, 642-, and 10000-fold selectivity over α_1A-,α_1B-, andα_1D-AR, respectively. ANO1-IN-5 exhibits significant inhibitory effects on osteoclast differentiation and function. ANO1-IN-5 can used for the study of osteoporosis.

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Formel: C₂₃H₃₃N₃O₄S
Molecular Weight:447.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ANO1-IN-5 Chemical Structure

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

ANO1-IN-5 (Compound 10) (20 μM, 5 d) significantly inhibits the formation of TRAP⁺ multinucleated osteoclasts^[1].
ANO1-IN-5 (20 μM) significantly reduces the mRNA expression of osteoclast marker genes such as NFATc1, Acp5, Ctsk, and Mmp9^[1].
ANO1-IN-5 directly suppresses the Cl^- secretion function of osteoclasts by inhibiting ANO1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	T_1/2	C_max	AUC_0-t	AUC_0-∞	Cl_{F_obs}	V_{z-F_obs}	F
Rat^[1]	1 mg/kg	i.v.	0.083 h	1.62 h	2513 ng/mL	1520 ng·h/mL	1520 ng·h/mL	0.64 L/h/kg	0.77 L/kg	/
Rat^[1]	10 mg/kg	p.o.	4.00 h	2.76 h	331.3 ng/mL	2460 ng·h/mL	2469 ng·h/mL	4.11 L/kg	/	16.2 %

In Vivo

ANO1-IN-5 (Compound 10) (3-30 mg/kg, i.g., once daily for 4 weeks) effectively alleviates ovariectomy (OVX)-induced bone loss, significantly improving trabecular bone mass and morphological parameters in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OVX-induced bone loss model established in 6-8-week-old female mice^[1]
Dosage:

3, 10 and 30 mg/kg
Administration:

Intragastrical administration (i.g.), once daily for 4 weeks
Result:

Exhibited higher bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) values, but a lower trabecular separation (Tb.Sp) in a dose-dependent manner.
Reduced the level of the bone resorption marker CTX-1 in the serum, and downregulated the expression of osteoclast marker genes in the bone tissue.

Chemical Information

Molecular Weight 447.59
Formel C₂₃H₃₃N₃O₄S
SMILES

O=S(C1=CC(CC(NC2CCN(C3=CC=CC=C3OCC)CC2)C)=CC=C1OC)(N)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tian C, et al. Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1-Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents. J Med Chem. 2025 Aug 28;68(16):17705-17722. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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