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AR antagonist 12

AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist wiith IC50 values of 119.3 μM and 98.2 μM for wt-AR and AR-F877L,respectively. AR antagonist 12 induces a dose-dependent and time-dependent reduction in AR, AR-V7, and PSA protein levels. AR antagonist 1 shows anticancer activuty and can be used for the study of Enzalutamide (HY-70002)-resistant Prostate cancer.

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  • CAS. Nr.: 2902679-42-7
  • Formel: C24H23F3N6O2
  • Molecular Weight:484.47
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • AR antagonist 12 Chemical Structure
    AR antagonist 12 Chemical Structure
CAS. Nr.: 2902679-42-7
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    AR antagonist 12 Chemical Structure
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  • AR antagonist 12