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Art. -Nr.: HY-117803

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CP 461 free base

(Synonyms: OSI-461 free base)

CP 461 free base (OSI-461 free base) is a novel pro-apoptotic compound with the activity of inhibiting cyclic guanosine monophosphate phosphodiesterase. CP 461 free base exhibits growth inhibitory activity against a variety of human tumor cell lines in vitro. CP 461 free base selectively induces apoptosis in cancer cell lines but has no effect on normal cells. CP 461 free base can be used in the study of renal cell carcinoma, prostate cancer and Crohn's disease.

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CAS. Nr.: 227619-92-3
Formel: C₂₅H₂₁FN₂O
Molecular Weight:384.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CP 461 free base Chemical Structure

CAS. Nr.: 227619-92-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	CC₅₀	2.14 μM Compound: 86	Growth inhibition of human HT-29 cells after 72 hrs by CellTiter-Glo reagent based assay Growth inhibition of human HT-29 cells after 72 hrs by CellTiter-Glo reagent based assay	[PMID: 28935266]
MDA-MB-231	CC₅₀	3.68 μM Compound: 86	Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Glo reagent based assay Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Glo reagent based assay	[PMID: 28935266]
PC-3	CC₅₀	5.71 μM Compound: 86	Growth inhibition of human PC3 cells after 72 hrs by CellTiter-Glo reagent based assay Growth inhibition of human PC3 cells after 72 hrs by CellTiter-Glo reagent based assay	[PMID: 28935266]

Chemical Information

CAS. Nr. 227619-92-3
Molecular Weight 384.45
Formel C₂₅H₂₁FN₂O
SMILES

O=C(NCC1=CC=CC=C1)CC(C2=CC(F)=CC=C2/3)=C(C)C3=C\C4=CC=NC=C4
Synonyms

OSI-461 free base
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Phase I and pharmacokinetic trial of the proapoptotic sulindac analog CP-461 in patients with advanced cancer [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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