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Dexrazoxane monohydrochloride

14 Cited Publications
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Dexrazoxane monohydrochloride is the hydrochloride of Dexrazoxane (HY-B0581). Dexrazoxane can prevent or reduce cardiac damage and is an iron chelator and apoptosis inducer. Dexrazoxane has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities and inhibits ferroptosis.

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  • CAS. Nr.: 1263283-43-7
  • Formel: C11H17ClN4O4
  • Molecular Weight:304.73
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Dexrazoxane monohydrochloride Chemical Structure
    Dexrazoxane monohydrochloride Chemical Structure
  • Experimental Validation Results for Dexrazoxane monohydrochloride
  • Experimental Validation Results for Dexrazoxane monohydrochloride
  • Experimental Validation Results for Dexrazoxane monohydrochloride
  • Experimental Validation Results for Dexrazoxane monohydrochloride
  • Experimental Validation Results for Dexrazoxane monohydrochloride
CAS. Nr.: 1263283-43-7
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  • Dexrazoxane monohydrochloride Chemical Structure
    Dexrazoxane monohydrochloride Chemical Structure
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    Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]

    Customer Validation
     Dexrazoxane (DXZ) (1 µM; 24 h) resulted in a decline in contractile speed in NMCMs.

  • 1/16

    Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]

    Customer Validation
     Dexrazoxane (DXZ) (1 µM; 24 h) resulted in a decline in cell viability in NMCMs.

  • 1/16

    Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]

    Customer Validation
     Dexrazoxane (DXZ) (1 µM; 24 h) inhibited DOX-induced iron accumulation and ROS and restored mitochondrial membrane potential in NMCMs.

  • 1/16

    Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]

    Customer Validation
     Dexrazoxane (DXZ) (1 µM; 24 h) reversed Ptgs2 mRNA expression in NMCMs.

  • 1/16

    Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]

    Customer Validation
     Dexrazoxane (DXZ) (20 mg/kg; i.p.; weekly for 4 weeks) reversed the DOX-induced decrease in body weight and the ratio of heart weight to tibia length (HW/TL) of chronic DoIC (doxorubicin (DOX)-induced cardiotoxicity) mice.

  • Dexrazoxane monohydrochloride