LDLRAD3 - low density lipoprotein receptor class A domain containing 3 Gene

Also Known as LRAD3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 143458

About LDLRAD3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,944,062-36,232,136 (from NCBI)

This gene has 6 transcripts (splice variants) and 168 orthologues. Ubiquitous expression in brain (RPKM 8.5), prostate (RPKM 7.2) and 25 other tissues.

Summary

Predicted to enable amyloid-beta binding activity. Predicted to act upstream of or within receptor-mediated endocytosis and regulation of protein processing. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

LDLRAD3 Products (3)

mRNA	Protein	Name
NM_001304263.2	NP_001291192.1	low-density lipoprotein receptor class A domain-containing protein 3 isoform 2 precursor
NM_001304264.2	NP_001291193.1	low-density lipoprotein receptor class A domain-containing protein 3 isoform 3
NM_174902.4	NP_777562.1	low-density lipoprotein receptor class A domain-containing protein 3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26854353	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDLRAD3 Protein Structure

Ldl_recept_a

0
100
200
300
345 a.a.

Protein Preferred Names	Protein Names
low-density lipoprotein receptor class A domain-containing protein 3	LDLR class A domain-containing protein 3

Recombinant LDLRAD3 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P77057	LDLRAD3 Protein, Human (HEK293, Fc, solution)	Q86YD5-1/NP_777562.1 (Q18-T173)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Postinflammatory Pulmonary Fibrosis	Post-Inflammatory Pulmonary Fibrosis
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07578	LDLRAD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21244	Ldlrad3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27761	Ldlrad3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991766	Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LDLRAD3	RGD	RGD:1307846
Macaca mulatta	LDLRAD3	VGNC	VGNC:74137
Felis catus	LDLRAD3	VGNC	VGNC:82035
Mus musculus	LDLRAD3	MGD	MGI:2138856
Bos taurus	LDLRAD3	VGNC	VGNC:30828
Canis familiaris	LDLRAD3	VGNC	VGNC:42624
Others	LDLRAD3	NCBI