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  3. LDLRAD3 Protein, Human (HEK293, Fc)

LDLRAD3 Protein, Human (HEK293, Fc)

Cat. No.: HY-P77057
COA Handling Instructions

LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, Fc) is the recombinant human-derived LDLRAD3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LDLRAD3 Protein, Human (HEK293, Fc) is 156 a.a., with molecular weight of ~43.8 KDa.

For research use only. We do not sell to patients.

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Description

LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, Fc) is the recombinant human-derived LDLRAD3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LDLRAD3 Protein, Human (HEK293, Fc) is 156 a.a., with molecular weight of ~43.8 KDa.

Background

The LDLRAD3 protein appears to have a significant impact on amyloid precursor protein (APP) processing, potentially leading to decreased production of soluble APP-alpha (sAPP-alpha) and an increase in the generation of the amyloidogenic P3 peptide. Furthermore, it is suggested to play a regulatory role in the activity and degradation of ITCH and NEDD4 E3 ligases, as indicated by studies. In the context of microbial infection, LDLRAD3 acts as a receptor for the Venezuelan equine encephalitis virus. These findings underscore the multifunctional nature of LDLRAD3, implicating it in key cellular processes related to protein processing, immune response, and viral interactions.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

Q86YD5/NP_777562.1 (Q18-T173)

Gene ID
Molecular Construction
N-term
LDLRAD3 (Q18-T173)
Accession # Q86YD5/NP_777562.1
hFc
C-term
Synonyms
Low-density lipoprotein receptor class A domain-containing protein 3; LRAD3
Molecular Weight

Approximately 43.8 kDa.

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

LDLRAD3 Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
LDLRAD3 Protein, Human (HEK293, Fc)
Cat. No.:
HY-P77057
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