LDLRAD3 Protein, Human (HEK293, Fc, solution)
Based on 1 Customer Validation
LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, Fc, solution) is the recombinant human-derived LDLRAD3 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Human
- Source: HEK293
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, Fc, solution) is the recombinant human-derived LDLRAD3 protein, expressed by HEK293 , with C-hFc labeled tag.
Background
The LDLRAD3 protein appears to have a significant impact on amyloid precursor protein (APP) processing, potentially leading to decreased production of soluble APP-alpha (sAPP-alpha) and an increase in the generation of the amyloidogenic P3 peptide. Furthermore, it is suggested to play a regulatory role in the activity and degradation of ITCH and NEDD4 E3 ligases, as indicated by studies. In the context of microbial infection, LDLRAD3 acts as a receptor for the Venezuelan equine encephalitis virus. These findings underscore the multifunctional nature of LDLRAD3, implicating it in key cellular processes related to protein processing, immune response, and viral interactions.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
Q86YD5-1/NP_777562.1 (Q18-T173)
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Molecular Construction
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N-term
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LDLRAD3 (Q18-T173)
Accession # Q86YD5-1/NP_777562.1 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
LDLRAD3; Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3; Low Density Lipoprotein Receptor Class A Domain Containing 3; LDLR Class A Domain-Containing Protein 3; LRAD3
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AA Sequence
QLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT
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Predicted Molecular Mass
43.8 kDa
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Molecular Weight
Approximately 58-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Shipping with dry ice.
Documentation
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Data Sheet (233 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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