BROX - BRO1 domain and CAAX motif containing Gene

Also Known as C1orf58

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 148362

About BROX

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in colon (RPKM 10.5), brain (RPKM 10.3) and 25 other tissues.

Summary

Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

BROX Products (6)

mRNA	Protein	Name
NM_001288579.2	NP_001275508.1	BRO1 domain-containing protein BROX isoform b
NM_001288580.2	NP_001275509.1	BRO1 domain-containing protein BROX isoform b
NM_001288581.2	NP_001275510.1	BRO1 domain-containing protein BROX isoform c
NM_001375661.1	NP_001362590.1	BRO1 domain-containing protein BROX isoform a
NM_001375758.1	NP_001362687.1	BRO1 domain-containing protein BROX isoform d
NM_144695.4	NP_653296.2	BRO1 domain-containing protein BROX isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22162750	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in mitotic nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	34818527	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	34818527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BROX Protein Structure

BRO1

0
100
200
300
411 a.a.

Protein Preferred Names	Protein Names
BRO1 domain-containing protein BROX

BROX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BROX	Q5VW32	CHMP5	Homo sapiens	Q9NZZ3-1	FPS	22484091
Intra	BROX	Q5VW32	CHMP5	Homo sapiens	Q9NZZ3-1	Anti Tag CoIP	22484091
Intra	BROX	Q5VW32	CHMP5	Homo sapiens	Q9NZZ3-1	X-Ray Diffraction	22484091
Intra	BROX	Q5VW32	TCEA1	Homo sapiens	P23193	Anti Tag CoIP	33961781
Intra	BROX	Q5VW32	TCEA1	Homo sapiens	P23193	Anti Tag CoIP	28514442
Intra	BROX	Q5VW32	CHMP4B	Homo sapiens	Q9H444	X-Ray Diffraction	22484091
Intra	BROX	Q5VW32	CHMP4B	Homo sapiens	Q9H444	Anti Tag CoIP	22484091
Intra	BROX	Q5VW32	CHMP4B	Homo sapiens	Q9H444	FPS	22484091

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Central Nervous System Sarcoma	Sarcoma Of The Cns
Developmental And Epileptic Encephalopathy 12	Epileptic Encephalopathy, Early Infantile, 12 DEE12 Eiee12 Early Infantile Epileptic Encephalopathy 12 Developmental And Epileptic Encephalopathy, 12 Encephalopathy, Epileptic, Early Infantile, Type 12
Breast Ductal Adenoma
Methemoglobinemia And Ambiguous Genitalia	METAG Methemoglobinemia Type Iv Isolated 17,20-Lyase Deficiency, Pure Methemoglobinemia Due To Deficiency Of Cytochrome B5 Methemoglobinemia Type 4 Methemoglobinemia Type Iv, Formerly Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly Pure Isolated 17,20-Lyase Deficiency Methemoglobinemia, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01627	BROX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22111	Brox Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28633	Brox Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BROX	VGNC	VGNC:26571
Felis catus	BROX	VGNC	VGNC:60180
Canis familiaris	BROX	VGNC	VGNC:38532
Rattus norvegicus	BROX	RGD	RGD:1307161
Macaca mulatta	BROX	VGNC	VGNC:70399
Mus musculus	BROX	MGD	MGI:1918928
Others	BROX	NCBI