TCEA1 - transcription elongation factor A1 Gene

Also Known as SII; TCEA; TF2S; GTF2S; TFIIS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6917

About TCEA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,966,556-54,022,448 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues, 3 paralogues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 66.3), lymph node (RPKM 39.6) and 25 other tissues.

Summary

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

TCEA1 Products (2)

mRNA	Protein	Name
NM_006756.4	NP_006747.1	transcription elongation factor A protein 1 isoform 1
NM_201437.3	NP_958845.1	transcription elongation factor A protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20178742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCEA1 Protein Structure

Med26

TFIIS_M

TFIIS_C

0
100
200
301 a.a.

Protein Preferred Names	Protein Names
transcription elongation factor A protein 1	epididymis secretory sperm binding protein

TCEA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCEA1	P23193	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	20178742
Intra	TCEA1	P23193	PAF1	Homo sapiens	Q8N7H5	Pull Down	20178742
Intra	TCEA1	P23193	POLR2A	Homo sapiens	P24928	Pull Down	20178742
Intra	TCEA1	P23193	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	20178742
Intra	TCEA1	P23193	POLR2A	Homo sapiens	P24928	Pull Down	20562857
Intra	TCEA1	P23193	GPKOW	Homo sapiens	Q92917	Y2H Prey Pooling	32296183
Intra	TCEA1	P23193	GPKOW	Homo sapiens	Q92917	Validated Y2H	32296183
Intra	TCEA1	P23193	GPKOW	Homo sapiens	Q92917	Y2H Array	32296183
Intra	TCEA1	P23193	LEO1	Homo sapiens	Q8WVC0	Pull Down	20178742
Intra	TCEA1	P23193	LEO1	Homo sapiens	Q8WVC0	Anti Bait CoIP	20178742

Cross: Cross-species interaction Intra: Intraspecies interaction

TCEA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82413	TCEA1 Antibody (YA2158)	WB	Human, Mouse, Rat, Monkey
HY-P82413A	TCEA1 Antibody (YA2158)(PBS only)	WB	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
De Sanctis-Cacchione Syndrome	Xerodermic Idiocy Xeroderma Pigmentosum With Neurologic Manifestation DSC Xerodermic Idiocy Of De Sanctis And Cacchione
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14292	TCEA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TCEA1	VGNC	VGNC:78279
Mus musculus	TCEA1	MGD	MGI:1196624
Bos taurus	TCEA1	VGNC	VGNC:35679
Rattus norvegicus	TCEA1	RGD	RGD:1309880
Felis catus	TCEA1	VGNC	VGNC:81681
Canis familiaris	TCEA1	VGNC	VGNC:47182
Others	TCEA1	NCBI