TCEA1 - transcription elongation factor A1 Gene

Homo sapiens

Also known as SII; TCEA; TF2S; GTF2S; TFIIS

Gene ID: 6917 | Gene type: protein coding

About TCEA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,966,556-54,022,448 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues, 3 paralogues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 66.3), lymph node (RPKM 39.6) and 25 other tissues.

Summary

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

TCEA1 Products(2)

mRNA	Protein	Name
NM_006756.4	NP_006747.1	transcription elongation factor A protein 1 isoform 1
NM_201437.3	NP_958845.1	transcription elongation factor A protein 1 isoform 2

TCEA1 Protein Structure

Med26

TFIIS_M

TFIIS_C

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

transcription elongation factor A protein 1

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Uv-Sensitive Syndrome

Uvss	Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome

De Sanctis-Cacchione Syndrome

Xerodermic Idiocy	Xeroderma Pigmentosum With Neurologic Manifestation
DSC	Xerodermic Idiocy Of De Sanctis And Cacchione

Cockayne Syndrome B

Cockayne Syndrome Type 2	Cockayne Syndrome, Type B
Cockayne Syndrome Type Ii	CSB
Cockayne Syndrome 2	Cockayne Syndrome Type B
Ckn2	Cockayne Syndrome, Type Ii

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14292	TCEA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TCEA1	VGNC	VGNC:78279
Mus musculus	TCEA1	MGD	MGI:1196624
Bos taurus	TCEA1	VGNC	VGNC:35679
Rattus norvegicus	TCEA1	RGD	RGD:1309880
Felis catus	TCEA1	VGNC	VGNC:81681
Canis familiaris	TCEA1	VGNC	VGNC:47182

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