Adra2b - adrenoceptor alpha 2B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24174

Summary

Enables alpha2-adrenergic receptor activity. Involved in several processes, including female pregnancy; positive regulation of MAPK cascade; and regulation of smooth muscle contraction. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]

Adra2b Products (1)

mRNA Protein Name
NM_138505.2 NP_612514.2 alpha-2B adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables alpha2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
2158103 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
27901063 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
19450576 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
11891218 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
17070424 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
17664026 RGD
involved in regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18054907 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2B adrenergic receptor

  • Adrenergic alpha2B- receptor class III

  • Adrenergic, alpha2B-, receptor class III

  • adrenergic receptor, alpha 2b

  • adrenergic, alpha-2B-, receptor

  • alpha-2B adrenoceptor

  • alpha-2B adrenoreceptor

  • alpha-2BAR

Adra2b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Adra2b P19328 GGA1 Homo sapiens Q9UJY5
Pull Down
27901063
Cross
Adra2b P19328 GGA2 Homo sapiens Q9UJY4
Pull Down
27901063
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00412 ADRA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra2b NCBI NCBI:151