Adra2b - adrenoceptor alpha 2B Gene

Rattus norvegicus

Gene ID: 24174 | Gene type: protein coding

About Adra2b

Summary

Enables alpha2-adrenergic receptor activity. Involved in several processes, including female pregnancy; positive regulation of MAPK cascade; and regulation of smooth muscle contraction. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]

Adra2b Products(1)

mRNA	Protein	Name
NM_138505.2	NP_612514.2	alpha-2B adrenergic receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha2-adrenergic receptor activity	IDA IDA: Inferred from direct assay	2158103	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	27901063	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	19450576	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11891218	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17070424	RGD
involved in positive regulation of uterine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17664026	RGD
involved in regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18054907	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-2B adrenergic receptor

Adrenergic alpha2B- receptor class III	Adrenergic, alpha2B-, receptor class III
adrenergic receptor, alpha 2b	adrenergic, alpha-2B-, receptor
alpha-2B adrenoceptor	alpha-2B adrenoreceptor
alpha-2BAR

Adra2b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Adra2b	P19328	GGA1	Homo sapiens	Q9UJY5	Pull Down	27901063
Cross	Adra2b	P19328	GGA2	Homo sapiens	Q9UJY4	Pull Down	27901063

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00412	ADRA2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adra2b	NCBI	NCBI:151

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