RPS25 - ribosomal protein S25 Gene

Also Known as S25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6230

About RPS25

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,015,717-119,018,343 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 201 orthologues. Ubiquitous expression in ovary (RPKM 1368.6), lymph node (RPKM 772.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS25 Products (1)

mRNA Protein Name
NM_001028.3 NP_001019.1 40S ribosomal protein S25
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22720776 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
enables structural constituent of ribosome IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
18697920 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
10050887 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
is active in postsynaptic density EXP
EXP: Inferred from Experiment
21170055 GOA
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21170055 GOA
located in ribosome IDA
IDA: Inferred from direct assay
1748303 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS25 Protein Structure

Ribosomal_S25

Ribosomal_S25: S25 ribosomal protein (1 - 113)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S25

  • small ribosomal subunit protein eS25

RPS25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RPS25 P62851 ZBTB14 Homo sapiens O43829 32296183
Intra
RPS25 P62851 ZBTB14 Homo sapiens O43829 32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76 32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76 32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76 32296183
Intra
RPS25 P62851 NKAPD1 Homo sapiens Q6ZUT1 32296183
Intra
RPS25 P62851 THAP1 Homo sapiens Q9NVV9 25416956
Intra
RPS25 P62851 THAP1 Homo sapiens Q9NVV9 25416956
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2 32296183
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2 32296183
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2 32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4 32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4 32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 5q Deletion Syndrome
  • 5q- Syndrome

  • Mar

  • Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality

  • Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic

  • 5q Deletion Syndrome

  • 5q Minus Syndrome

  • Refractory Macrocytic Anemia Due To 5q Deletion

  • Myelodysplastic Syndrome With Isolated Del

  • Macrocytic Anemia, Refractory, Due To 5q Deletion

  • 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion

  • 5q Syndrome

  • Chromosome 5q Deletion

  • Myelodysplastic Syndrome With 5q Deletion

  • Myelodysplastic Syndrome With 5q Deletion Syndrome

  • Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic

  • 5q-Syndrome

  • Chromosome 5, Trisomy 5q

  • Loss Of Chromosome 5q

  • 5 Q- Syndrome

Diamond-Blackfan Anemia
  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPS25 RGD RGD:621043
Mus musculus RPS25 MGD MGI:1922867
Others RPS25 NCBI