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Art. -Nr.: HY-169296

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IMPDH2-IN-4

IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a K_i,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₅H₃₄O₆Si
Molecular Weight:578.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IMPDH2-IN-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IMPDH2

1.8 μM (Ki app)

In Vitro

IMPDH2-IN-4 (0.1-100.0 μM for hFOB; 72 h) potently inhibits the viability of 143B, MNNG/HOS, U2OS and SaOS-2 osteosarcoma cells, with IC₅₀ values ranging from 0.64 to 2.27 μM, while exhibiting low cytotoxicity toward normal osteoblastic hFOB 1.19 cells^[1].
IMPDH2-IN-4 inhibits recombinant IMPDH2 with a K_i,app of 1.8 μM, and does not inhibit IMPDH1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

143B, MNNG/HOS, U2OS, SaOS-2, hFOB 1.19
Concentration:

0.1 μM, 1.0 μM, 10.0 μM, 100.0 μM for hFOB 1.19
Incubation Time:

72 h
Result:

Inhibited viability of 143B cells with an IC₅₀ of 1.65 μM.
Inhibited viability of MNNG/HOS cells with an IC₅₀ of 0.64 μM.
Inhibited viability of U2OS cells with an IC₅₀ of 1.01 μM.
Inhibited viability of SaOS-2 cells with an IC₅₀ of 2.27 μM.
Reduced hFOB 1.19 cell viability to 93.91% at 0.1 μM, 91.95% at 1.0 μM, 84.5% at 10.0 μM, and 73.34% at 100.0 μM.

Chemical Information

Molecular Weight 578.73
Formel C₃₅H₃₄O₆Si
SMILES

O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC/C(C)=C/CC4=C(O)C5=C(COC5=O)C(C)=C4OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Silalai P, et al. Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment. ACS Bio Med Chem Au. 2024;5(1):106-118. Published 2024 Oct 17. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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