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Art. -Nr.: HY-181772

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MCULE-3064932370

MCULE-3064932370 is a covalent and allosteric SUMO E1 (heterodimer of Aos1 and Uba2) inhibitor with IC₅₀ values ranging from 16.66 μM to 2.96 μM. MCULE-3064932370 inhibits SUMOylation of Uba2. MCULE-3064932370 has anti-cancer activity against breast cancer.

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CAS. Nr.: 315698-78-3
Formel: C₁₈H₁₂N₂O₃S₂
Molecular Weight:368.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

MCULE-3064932370 Chemical Structure

CAS. Nr.: 315698-78-3

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

MCULE-3064932370 (0-100 μM; 0-1.5 h pre-incubation) time-dependently and concentration-dependently inhibits purified human SUMO E1 (Aos1/Uba2 complex) activity, with IC₅₀ values ranging from 16.66 ± 9.55 μM to 2.96 ± 1.61 μM over 0 to 1.5 hours of pre-incubation^[1].
MCULE-3064932370 (0.1-100 μM; 24-48 h) concentration-dependently inhibits T47D breast cancer cell proliferation, with EC₅₀ values of 20.79 ± 3.26 μM (24 h) and 10.40 ± 4.58 μM (48 h)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay^[1]

Cell Line:

Human T47D breast cancer cells
Concentration:

12.5 μM, 25 μM
Incubation Time:

24 h
Result:

Reduced relative cell migration to 0.54 (12.5 μM) and 0.32 (25 μM) of vehicle control.

Chemical Information

CAS. Nr. 315698-78-3
Molecular Weight 368.43
Formel C₁₈H₁₂N₂O₃S₂
SMILES

O=C(C(SC#N)=C/1)C2=CC=CC=C2C1=N\S(=O)(C3=CC=C(C)C=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang S, et al. SUMO E1 covalent allosteric inhibitors upregulate polyamine synthesis via the MAT2A-AdoMetDC axis. Bioorg Chem. 2025;164:108930. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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