Mivacurium dichloride
Based on 1 Customer Validation
Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.
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- Reinheit: 99.00%
- CAS. Nr.: 106861-44-3
- Formel: C58H80Cl2N2O14
- Molecular Weight:1100.17
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Speicherung:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 106861-44-3
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Appearance Solid
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Molecular Weight 1100.17
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Formel C58H80Cl2N2O14
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Color White to off-white
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SMILES
O=C(OCCC[N+]1(C)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)CC/C=C/CCC(OCCC[N+]4(C)[C@H](CC5=CC(OC)=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O.[Cl-].[Cl-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (227.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (90.90 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128. [Content Brief]
[2]. Matthias Paul, et al. The Potency of New Muscle Relaxants on Recombinant Muscle-Type Acetylcholine Receptors. Anesth Analg. 2002 Mar;94(3):597-603; table of contents. [Content Brief]
[3]. J E Caldwell. New Skeletal Muscle Relaxants. Int Anesthesiol Clin. Winter 1995;33(1):39-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.9090 mL | 4.5448 mL | 9.0895 mL | 22.7238 mL |
| 5 mM | 0.1818 mL | 0.9090 mL | 1.8179 mL | 4.5448 mL | |
| 10 mM | 0.0909 mL | 0.4545 mL | 0.9090 mL | 2.2724 mL | |
| 15 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5149 mL | |
| 20 mM | 0.0454 mL | 0.2272 mL | 0.4545 mL | 1.1362 mL | |
| 25 mM | 0.0364 mL | 0.1818 mL | 0.3636 mL | 0.9090 mL | |
| 30 mM | 0.0303 mL | 0.1515 mL | 0.3030 mL | 0.7575 mL | |
| 40 mM | 0.0227 mL | 0.1136 mL | 0.2272 mL | 0.5681 mL | |
| 50 mM | 0.0182 mL | 0.0909 mL | 0.1818 mL | 0.4545 mL | |
| 60 mM | 0.0151 mL | 0.0757 mL | 0.1515 mL | 0.3787 mL | |
| 80 mM | 0.0114 mL | 0.0568 mL | 0.1136 mL | 0.2840 mL | |
| DMSO | 100 mM | 0.0091 mL | 0.0454 mL | 0.0909 mL | 0.2272 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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