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Art. -Nr.: HY-P0307B

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Penetratin-Cys

Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders.

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CAS. Nr.: 393511-85-8
Formel: C₁₀₇H₁₇₃N₃₅O₂₁S₂
Molecular Weight:2349.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

Penetratin-Cys Chemical Structure

CAS. Nr.: 393511-85-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Penetratin-Cys dimer (50-400 μg/mL; 24 h) exhibits strong cytotoxicity against differentiated SH-SY5Y cells at the concentration of 400 μg/mL, and shows moderate cytotoxicity against HeLa cells and undifferentiated SH-SY5Y cells across the tested concentration range^[1].
Penetratin-Cys dimer (7 μM/liter; 2-24 h) efficiently enters HeLa cells and localizes to the perinuclear region associated with the Golgi apparatus after 24 h of incubation^[1].
Penetratin-Cys dimer exhibits weak antibacterial activity against E. coli, M. luteus, and S. aureus, with their MIC values ranging from 8 μmol/liter to >32 μmol/liter depending on the strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa, undifferentiated SH-SY5Y, differentiated SH-SY5Y
Concentration:

50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL
Incubation Time:

24 h
Result:

Reduced HeLa cell viability to levels below 60% at 400 μg/mL.
Reduced undifferentiated SH-SY5Y cell viability to levels similar to penetratin-PrAMP constructs at 200 μg/mL.
Reduced differentiated SH-SY5Y cell viability to ~30% at 400 μg/mL.

Immunofluorescence^[1]

Cell Line:

HeLa
Concentration:

7 μM/liter
Incubation Time:

2 h, 24 h
Result:

Entered HeLa cells and aligned perinuclear in small distinct spots after 2 h.
Formed a dense cloud associated with the Golgi apparatus after 24 h.

Chemical Information

CAS. Nr. 393511-85-8
Molecular Weight 2349.87
Formel C₁₀₇H₁₇₃N₃₅O₂₁S₂
Sequence

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys
Sequence Shortening

RQIKIWFQNRRMKWKKC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hansen A, et al. Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin. Antimicrob Agents Chemother. 2012;56(10):5194-5201. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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