Sorbitol dehydrogenase
Based on 1 Customer Validation
Sorbitol dehydrogenase (L-Iditol dehydrogenase) is an oxidoreductasea and catalyses the conversion of sorbitol to fructose with NAD+ as the coenzyme. Sorbitol dehydrogenase catalyses pH-dependent redox reactions between NAD+/NADH and sorbitol/fructose. Sorbitol dehydrogenase is implicated in diabetic complications and is a biomarker of drug-induced liver injury. Sorbitol dehydrogenase can be used for the research of diabetes and liver injury.
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- CAS. Nr.: 9028-21-1
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Sorbitol dehydrogenase exhibits substrate inhibition at sorbitol concentrations >30 mM and fructose concentrations >100 mM at pH 7.4, with dissociation of the enzyme-coenzyme binary complex as the rate-limiting reaction step[1].
Sorbitol dehydrogenase exhibits higher apparent affinity for fructose and NADH than for sorbitol and NAD+[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 9028-21-1
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Appearance Solid
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Color White to off-white
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SMILES
[Sorbitol dehydrogenase]
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Synonyms
L-Iditol dehydrogenase; Polyol dehydrogenase; SDH
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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