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Art. -Nr.: HY-14804A

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Tasisulam sodium

(Synonyms: LY 573636 sodium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.

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CAS. Nr.: 519055-63-1
Formel: C₁₁H₅BrCl₂NNaO₃S₂
Molecular Weight:437.09

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tasisulam sodium Chemical Structure

CAS. Nr.: 519055-63-1

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Beschreibung

In Vitro

Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC₅₀s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively^[1].
Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation^[1].
Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models^[1].
Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration:

200 nM-200 μM
Incubation Time:

48 hours
Result:

Induced an antiproliferative response across a wide range of tumor histologies with EC₅₀s is 10 μM and 25 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

Calu-6 and A-375 cell lines
Concentration:

25, 50 μM
Incubation Time:

72 hours
Result:

Induced a concentration-dependent increase in 4N DNA and G2-M accumulation.

Apoptosis Analysis^[1]

Cell Line:

Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration:

200 nM-200 μM
Incubation Time:

48 hours
Result:

Induced apoptosis in a broad range of in vitro cancer cell models.

Chemical Information

CAS. Nr. 519055-63-1
Molecular Weight 437.09
Formel C₁₁H₅BrCl₂NNaO₃S₂
SMILES

O=C(N([Na])S(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl
Synonyms

LY 573636 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10(11):2168-78. [Content Brief]

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tasisulam sodium

1 Cited Publications

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Tasisulam sodium

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HY-14804A Related Classifications