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Art. -Nr.: HY-P5277

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TAT-GluN2BCTM

TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection.

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CAS. Nr.: 1587742-50-4
Formel: C₂₂₄H₃₇₄N₈₆O₅₄
Molecular Weight:5135.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TAT-GluN2BCTM Chemical Structure

CAS. Nr.: 1587742-50-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

DAPK1^[1].

In Vitro

TAT-GluN2BCTM (200 µM; 0.5, 2, 4 h) results in a time-dependent reduction in DAPK1 levels in NMDA-treated primary neuronal cultures ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

primary neuronal cultures (NMDA-treated)
Concentration:

200 µM
Incubation Time:

0.5, 2, 4 h
Result:

Reduced DAPK1 levels in a time-dependent manner.

In Vivo

TAT-GluN2BCTM (10 mg/kg; i.v.; single) results in a significant reduction in DAPK1 levels only in the ischemic side of the brain in rats^[1].
TAT-GluN2BCTM (10 mg/kg; i.v.; single) shows prominent neuroprotection in the cortex and striatum of rats^[1].
TAT-GluN2BCTM is capable of specific knockdown of the active (but not inactive) form of DAPK1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Focal ischemia rat model^[1].
Dosage:

10 mg/kg
Administration:

Intravenous injection; single.
Result:

Reduced the levels of DAPK1 only in the ischemic side of the brain.
Significantly reduced the numbers of degenerating neurons in both striatum and cortical areas.

Chemical Information

CAS. Nr. 1587742-50-4
Molecular Weight 5135.91
Formel C₂₂₄H₃₇₄N₈₆O₅₄
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Lys-Phe-Glu-Arg-Gln-Lys-Ile-Leu-Asp-Gln-Arg-Phe-Phe-Glu
Sequence Shortening

YGRKKRRQRRRKKNRNKLRRQHSYKFERQKILDQRFFE
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fan X, et al. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation. Nat Neurosci. 2014 Mar;17(3):471-80. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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