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Telomerase-IN-7

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM.

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CAS. Nr.: 444320-44-9
Formel: C₂₄H₃₀N₂O₆
Molecular Weight:442.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Telomerase-IN-7 Chemical Structure

CAS. Nr.: 444320-44-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	26.892 μM Compound: 9	Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
GES1	IC₅₀	>1000 μM Compound: 9	Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
HL-60	IC₅₀	155.651 μM Compound: 9	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]

Chemical Information

CAS. Nr. 444320-44-9
Molecular Weight 442.50
Formel C₂₄H₃₀N₂O₆
SMILES

O=C(C(/C1=C/C2=CC=C(C=C2)OCC(NC(C)C)=O)=C(C)N(CC3OCCC3)C1=O)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zuo H, et al. Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity[J]. ACS Medicinal Chemistry Letters, 2024.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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