BCL2L14 - BCL2 like 14 Gene

Also Known as BCLG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79370

About BCL2L14

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:12,049,861-12,099,695 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 165 orthologues and 1 paralogue. Biased expression in testis (RPKM 9.1), duodenum (RPKM 7.7) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce Apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

BCL2L14 Products (5)

mRNA Protein Name
NM_001370268.1 NP_001357197.1 apoptosis facilitator Bcl-2-like protein 14 isoform 1
NM_001370269.1 NP_001357198.1 apoptosis facilitator Bcl-2-like protein 14 isoform 1
NM_030766.2 NP_110393.1 apoptosis facilitator Bcl-2-like protein 14 isoform 2
NM_138722.2 NP_620048.1 apoptosis facilitator Bcl-2-like protein 14 isoform 1
NM_138723.2 NP_620049.1 apoptosis facilitator Bcl-2-like protein 14 isoform 1
Protein Preferred Names Protein Names

apoptosis facilitator Bcl-2-like protein 14

  • BCL2-like 14 (apoptosis facilitator)

BCL2L14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL2L14 Q9BZR8 MELK Homo sapiens Q14680
Anti Tag CoIP
17280616
Intra
BCL2L14 Q9BZR8 MELK Homo sapiens Q14680
Protein Kinase Assay
17280616
Intra
BCL2L14 Q9BZR8 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
BCL2L14 Q9BZR8 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
BCL2L14 Q9BZR8 LGALS3BP Homo sapiens Q08380
Pull Down
30833792
Intra
BCL2L14 Q9BZR8 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
BCL2L14 Q9BZR8 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
BCL2L14 Q9BZR8 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
BCL2L14 Q9BZR8 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
BCL2L14 Q9BZR8 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

BCL2L14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82995 Bcl2 L14 Antibody (YA2740) WB, ICC/IF, IP Human, Mouse, Rat
HY-P82995A Bcl2 L14 Antibody (YA2740)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149624 Bcl-2-IN-14 Inhibitor / Unkown
HY-RS01432 BCL2L14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BCL2L14 MGD MGI:1914063
Canis familiaris BCL2L14 VGNC VGNC:38410
Bos taurus BCL2L14 VGNC VGNC:26448
Rattus norvegicus BCL2L14 RGD RGD:1562777
Felis catus BCL2L14 VGNC VGNC:60085
Macaca mulatta BCL2L14 VGNC VGNC:70083
Others BCL2L14 NCBI