MELK - maternal embryonic leucine zipper kinase Gene

Also Known as HPK38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9833

About MELK

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,572,895-36,677,682 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues.

Summary

Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MELK Products (53)

mRNA Protein Name
NM_001256688.2 NP_001243617.1 maternal embryonic leucine zipper kinase isoform 4
XM_047424189.1 XP_047280145.1 maternal embryonic leucine zipper kinase isoform X12
NR_046337.2
XM_047424204.1 XP_047280160.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424206.1 XP_047280162.1 maternal embryonic leucine zipper kinase isoform X19
XM_011518076.3 XP_011516378.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518082.3 XP_011516384.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256689.2 NP_001243618.1 maternal embryonic leucine zipper kinase isoform 5
XM_047424178.1 XP_047280134.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424191.1 XP_047280147.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424172.1 XP_047280128.1 maternal embryonic leucine zipper kinase isoform X5
NM_014791.4 NP_055606.1 maternal embryonic leucine zipper kinase isoform 1
XM_047424174.1 XP_047280130.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424188.1 XP_047280144.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424166.1 XP_047280122.1 maternal embryonic leucine zipper kinase isoform X1
NM_001256690.2 NP_001243619.1 maternal embryonic leucine zipper kinase isoform 6
XM_047424197.1 XP_047280153.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424182.1 XP_047280138.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424171.1 XP_047280127.1 maternal embryonic leucine zipper kinase isoform X4
NM_001256693.2 NP_001243622.1 maternal embryonic leucine zipper kinase isoform 9
NM_001256691.2 NP_001243620.1 maternal embryonic leucine zipper kinase isoform 7
XM_047424185.1 XP_047280141.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424183.1 XP_047280139.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424202.1 XP_047280158.1 maternal embryonic leucine zipper kinase isoform X17
NM_001256692.2 NP_001243621.1 maternal embryonic leucine zipper kinase isoform 8
XM_047424186.1 XP_047280142.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424198.1 XP_047280154.1 maternal embryonic leucine zipper kinase isoform X15
XM_047424180.1 XP_047280136.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424196.1 XP_047280152.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424177.1 XP_047280133.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424176.1 XP_047280132.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424179.1 XP_047280135.1 maternal embryonic leucine zipper kinase isoform X7
NM_001256685.2 NP_001243614.1 maternal embryonic leucine zipper kinase isoform 2
XM_047424170.1 XP_047280126.1 maternal embryonic leucine zipper kinase isoform X4
XM_047424193.1 XP_047280149.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424200.1 XP_047280156.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424195.1 XP_047280151.1 maternal embryonic leucine zipper kinase isoform X13
XM_011518077.2 XP_011516379.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518081.3 XP_011516383.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256687.2 NP_001243616.1 maternal embryonic leucine zipper kinase isoform 3
XM_047424173.1 XP_047280129.1 maternal embryonic leucine zipper kinase isoform X5
XM_047424169.1 XP_047280125.1 maternal embryonic leucine zipper kinase isoform X2
XM_011518085.2 XP_011516387.1 maternal embryonic leucine zipper kinase isoform X11
XM_047424184.1 XP_047280140.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424192.1 XP_047280148.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424194.1 XP_047280150.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424199.1 XP_047280155.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424205.1 XP_047280161.1 maternal embryonic leucine zipper kinase isoform X18
XM_047424181.1 XP_047280137.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424168.1 XP_047280124.1 maternal embryonic leucine zipper kinase isoform X2
XM_047424187.1 XP_047280143.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424203.1 XP_047280159.1 maternal embryonic leucine zipper kinase isoform X17
XM_011518080.1 XP_011516382.1 maternal embryonic leucine zipper kinase isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
16216881 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
16216881 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12400006 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12400006 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
17280616 GOA
involved in cell population proliferation IDA
IDA: Inferred from direct assay
17280616 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
16216881 GOA
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
16159311 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21145462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MELK Protein Structure

Pkinase

Pkinase: Protein kinase domain (11 - 263)

KA1

KA1: Kinase associated domain 1 (606 - 651)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
Protein Preferred Names Protein Names

maternal embryonic leucine zipper kinase

  • pEg3 kinase

  • protein kinase Eg3

  • protein kinase PK38

  • tyrosine-protein kinase MELK

MELK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MELK Q14680 BCL2L14 Homo sapiens Q9BZR8
Pull Down
17280616
Cross: Cross-species interaction Intra: Intraspecies interaction

MELK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81678 MELK Antibody (YA1423) WB Human
HY-P84573 MELK Antibody (YA4270) IHC-P, ICC/IF, FC, ELISA Human
HY-P84573A MELK Antibody (YA4270)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15512 OTSSP167 Inhibitor 99.27% Phase 2
HY-15512A OTSSP167 hydrochloride Inhibitor 99.78% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100368A MELK-8a hydrochloride Inhibitor 99.31% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-101515 MELK-IN-1 Inhibitor 98.03% Unkown
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.67% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-100368 MELK-8a Inhibitor 98.32% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155748 Antitumor agent-116 Inhibitor / Unkown
HY-N17632 Moracin G Inhibitor / Unkown
HY-12420A JNJ-47117096 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MELK RGD RGD:1308974
Canis familiaris MELK VGNC VGNC:51744
Bos taurus MELK VGNC VGNC:50031
Mus musculus MELK MGD MGI:106924
Macaca mulatta MELK VGNC VGNC:74521
Others MELK NCBI