2. Gene
  3. MELK - maternal embryonic leucine zipper kinase Gene

MELK - maternal embryonic leucine zipper kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HPK38

Gene ID: 9833 | Gene type: protein coding

About MELK

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,572,895-36,677,682 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues.

Summary

Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MELK Products(53)

mRNA Protein Name
NM_001256688.2 NP_001243617.1 maternal embryonic leucine zipper kinase isoform 4
XM_047424189.1 XP_047280145.1 maternal embryonic leucine zipper kinase isoform X12
NR_046337.2
XM_047424204.1 XP_047280160.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424206.1 XP_047280162.1 maternal embryonic leucine zipper kinase isoform X19
XM_011518076.3 XP_011516378.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518082.3 XP_011516384.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256689.2 NP_001243618.1 maternal embryonic leucine zipper kinase isoform 5
XM_047424178.1 XP_047280134.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424191.1 XP_047280147.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424172.1 XP_047280128.1 maternal embryonic leucine zipper kinase isoform X5
NM_014791.4 NP_055606.1 maternal embryonic leucine zipper kinase isoform 1
XM_047424174.1 XP_047280130.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424188.1 XP_047280144.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424166.1 XP_047280122.1 maternal embryonic leucine zipper kinase isoform X1
NM_001256690.2 NP_001243619.1 maternal embryonic leucine zipper kinase isoform 6
XM_047424197.1 XP_047280153.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424182.1 XP_047280138.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424171.1 XP_047280127.1 maternal embryonic leucine zipper kinase isoform X4
NM_001256693.2 NP_001243622.1 maternal embryonic leucine zipper kinase isoform 9
NM_001256691.2 NP_001243620.1 maternal embryonic leucine zipper kinase isoform 7
XM_047424185.1 XP_047280141.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424183.1 XP_047280139.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424202.1 XP_047280158.1 maternal embryonic leucine zipper kinase isoform X17
NM_001256692.2 NP_001243621.1 maternal embryonic leucine zipper kinase isoform 8
XM_047424186.1 XP_047280142.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424198.1 XP_047280154.1 maternal embryonic leucine zipper kinase isoform X15
XM_047424180.1 XP_047280136.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424196.1 XP_047280152.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424177.1 XP_047280133.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424176.1 XP_047280132.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424179.1 XP_047280135.1 maternal embryonic leucine zipper kinase isoform X7
NM_001256685.2 NP_001243614.1 maternal embryonic leucine zipper kinase isoform 2
XM_047424170.1 XP_047280126.1 maternal embryonic leucine zipper kinase isoform X4
XM_047424193.1 XP_047280149.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424200.1 XP_047280156.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424195.1 XP_047280151.1 maternal embryonic leucine zipper kinase isoform X13
XM_011518077.2 XP_011516379.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518081.3 XP_011516383.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256687.2 NP_001243616.1 maternal embryonic leucine zipper kinase isoform 3
XM_047424173.1 XP_047280129.1 maternal embryonic leucine zipper kinase isoform X5
XM_047424169.1 XP_047280125.1 maternal embryonic leucine zipper kinase isoform X2
XM_011518085.2 XP_011516387.1 maternal embryonic leucine zipper kinase isoform X11
XM_047424184.1 XP_047280140.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424192.1 XP_047280148.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424194.1 XP_047280150.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424199.1 XP_047280155.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424205.1 XP_047280161.1 maternal embryonic leucine zipper kinase isoform X18
XM_047424181.1 XP_047280137.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424168.1 XP_047280124.1 maternal embryonic leucine zipper kinase isoform X2
XM_047424187.1 XP_047280143.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424203.1 XP_047280159.1 maternal embryonic leucine zipper kinase isoform X17
XM_011518080.1 XP_011516382.1 maternal embryonic leucine zipper kinase isoform X2

MELK Protein Structure

Pkinase

Pkinase: Protein kinase domain (11 - 263)

KA1

KA1: Kinase associated domain 1 (606 - 651)

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  • 651 a.a.
Protein Preferred Names Protein Names

maternal embryonic leucine zipper kinase

pEg3 kinase

protein kinase Eg3

protein kinase PK38

tyrosine-protein kinase MELK

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15512A OTSSP167 hydrochloride Inhibitor 99.84% Phase 2
HY-15512 OTSSP167 Inhibitor 99.70% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.68% Unkown
HY-100368A MELK-8a hydrochloride Inhibitor 99.26% Unkown
HY-101515 MELK-IN-1 Inhibitor 98.67% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155748 Antitumor agent-116 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MELK RGD RGD:1308974
Canis familiaris MELK VGNC VGNC:51744
Bos taurus MELK VGNC VGNC:50031
Mus musculus MELK MGD MGI:106924
Macaca mulatta MELK VGNC VGNC:74521
Others MELK NCBI