Ru-TRZ2
Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity.
For research use only. We do not sell to patients.
- Formula: C45H43F6N4O7P2RuS2
- Molecular Weight:1092.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ru-TRZ2 (72 h) induces necroptosis with IC50s of 0.45, 0.24 µM for HCT116, HT29 cells, respectively[1].
Ru-TRZ2 induces mitochondrial depolarization and apoptotic cell death in HT29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Induced apoptosis and increased the expression of cleaved PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-10 weeks, Male nude mice[1]
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Dosage:5 mg/kg
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Administration:I.v.; every 2 days for 10 injections
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Result:Decreased the tumor weight in HT29 xenograft mice.
Chemical Information
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Molecular Weight 1092.98
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Formula C45H43F6N4O7P2RuS2
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SMILES
FC(F)(F)S(=O)([O-])=O.CN(C(CCC)=O)/N=N/C1=CC=C(C#[N][Ru+2]2([])[P](C3=CC=CC=C3)(C4=CC=CC=C4)CC[P]2(C5=CC=CC=C5)C6=CC=CC=C6)C=C1.FC(F)(F)S(=O)([O-])=O.C7CCCC7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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