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CK2-IN-11

CK2-IN-11 (32) is an allosteric CK2 inhibitor, with high selectivity for CK2 with IC₅₀ values of 19.3 nM and 15.6 nM for the CK2α2β2 and the CK2α′2β2 isoforms, respectively.

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CAS No.: 2938991-22-9
Formule: C₂₃H₂₂Br₄Cl₂N₄O₂
Masse moléculaire:776.97

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CK2-IN-11 Chemical Structure

CAS No.: 2938991-22-9

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

CK2-IN-11 (32) is an allosteric CK2 inhibitor, with high selectivity for CK2 with IC₅₀ values of 19.3 nM and 15.6 nM for the CK2α2β2 and the CK2α′2β2 isoforms, respectively^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	15.94 μM Compound: 2; KN2	Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay	[PMID: 34323071]
HeLa	EC₅₀	6.19 μM Compound: 2; KN2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay	[PMID: 34323071]

Chemical Information

CAS No. 2938991-22-9
Masse moléculaire 776.97
Formule C₂₃H₂₂Br₄Cl₂N₄O₂
SMILES

O=C(NCCCCN1C=NC2=C(C(Br)=C(C(Br)=C21)Br)Br)CCC(NCCC3=CC=C(C(Cl)=C3)Cl)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mustafa A Al-Qadhi, et al. Recent Advances in the Discovery of CK2 Inhibitors. ACS Omega. 2024 May 3;9(19):20702-20719. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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