Ferroptosis inducer-15
Ferroptosis inducer-15 is a ferroptosis inducer. Ferroptosis inducer-15 downregulates GPX4 expression, triggers lipid peroxidation via ROS accumulation, and disrupts mitochondrial membrane potential to drive ferroptosis. Ferroptosis inducer-15 increases splenic CD4+ T cell proportion, promotes CD8+ cytotoxic T cell tumor infiltration, and activates antitumor immune responses. Ferroptosis inducer-15 exerts antiproliferative activity against colorectal cancer cells and inhibits tumor growth in xenograft mice models without significant body weight loss. Ferroptosis inducer-15 can be used for the research of cancer, such as colorectal cancer.
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- CAS No.: 3097756-33-4
- Formule: C31H41NO10Se
- Masse moléculaire:666.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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GPX4 |
Ferroptosis inducer-15 (Compound 5k) (48 h) potently inhibits proliferation of HCT116 colorectal cancer cells with an IC50 of 0.81 μM, and shows variable antiproliferative activity against SW480, SW620, HT29, HepG2, and MCF-7 cells (IC50 = 2.43-21.84 μM)[1].
Ferroptosis inducer-15 induced cytotoxicity in HCT116 cells is dependent on ferroptosis, as indicated by reversal of cell death following co-treatment with ferroptosis-specific inhibitors[1].
Ferroptosis inducer-15 (1 μM; 24 h) significantly increases intracellular ROS, Fe2+ and lipid peroxidation levels in HCT116 colorectal cancer cells[1].
Ferroptosis inducer-15 (1 μM; 24 h) disrupts mitochondrial membrane potential and induces ferroptosis-associated mitochondrial morphological changes in HCT116 colorectal cancer cells[1].
Ferroptosis inducer-15 (0.5-2 μM; 24 h) downregulates SLC7A11, FTH1, and GPX4 expression and upregulates ACSL4 expression in HCT116 colorectal cancer cells, indicating induction of ferroptosis via the System Xc−/GPX4 pathway[1].
Ferroptosis inducer-15 (1 μM) directly binds to GPX4 protein in HCT116 colorectal cancer cells, enhancing GPX4 stability under increasing temperatures (40-60°C)[1].
Ferroptosis inducer-15 (0.5-2 μM) reduces GPX4 mRNA expression in a concentration-dependent manner in HCT116 colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 (colorectal adenocarcinoma)
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Concentration:1 μM
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Incubation Time:24 h
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Result:Increased the fluorescence intensity DCFH-DA.
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Cell Line:HCT116 (colorectal adenocarcinoma)
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Concentration:0.5, 1, 2 μM
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Incubation Time:24 h
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Result:Resulted in concentration-dependent downregulation of SLC7A11, FTH1, and GPX4 protein expression, and upregulation of ACSL4 protein expression in HCT116 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (5 weeks old, male/female, subcutaneous CT26 colon tumor cell implantation)[1]
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Dosage:25 mg/kg; 50 mg/kg
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Administration:i.p.; once every 2 days; 13 days
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Result:Achieved a tumor inhibition rate of 42.5%.
Achieved a tumor inhibition rate of 54.9%.
Did not induce significant body weight loss or obvious pathological changes in heart, liver, spleen, lung, or kidney tissues.
Increased the proportion of CD4+ T lymphocytes in the spleen by 1.3% and CD8+ T lymphocytes by 2.6% (at 25 mg/kg).
Increased the proportion of CD4+ T lymphocytes in the spleen by 6.2% and CD8+ T lymphocytes by 7.2% (at 50 mg/kg).
Chemical Information
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CAS No. 3097756-33-4
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Masse moléculaire 666.62
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Formule C31H41NO10Se
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SMILES
O=C(O[C@@H]1O[C@@]2([H])[C@@]3(OO[C@](O2)(C)CC4)[C@]4([H])[C@H](C)CC[C@@]3([H])[C@H]1C)CCC(OCCCCN5[Se]C6=CC(OC)=CC=C6C5=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferroptosis inducer-15 Related Classifications
HY-182802 Related Classifications
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- Ferroptosis inducer-15
- 3097756-33-4
- Ferroptosis inducer15
- Ferroptosis inducer 15
- Ferroptosis
- Glutathione Peroxidase
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- CD4+ T cell
- reactive oxygen species
- GPX4
- glutathione peroxidase 4
- ferroptosis
- colorectal cancer cells
- HCT116
- CD8+ cytotoxic T cell
- xenograft mouse models
- lipid peroxidation
- Inhibitor
- inhibitor
- inhibit