Ptpro - protein tyrosine phosphatase, receptor type, O Gene

Also Known as D28; PTPBK; PTPU2; PTPoc; GLEPP1; PTPROt; PTPphi; Ptpn15; R-PTP-O

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19277

Summary

Enables Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine Phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; plasma membrane bounded cell projection organization; and slit diaphragm assembly. Located in several cellular components, including apical plasma membrane; glutamatergic synapse; and lateral plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine Phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]

Ptpro Products (5)

mRNA	Protein	Name
NM_001164401.2	NP_001157873.1	receptor-type tyrosine-protein phosphatase O isoform 2 precursor
NM_001164402.2	NP_001157874.1	receptor-type tyrosine-protein phosphatase O isoform 3
NM_001164403.2	NP_001157875.1	receptor-type tyrosine-protein phosphatase O isoform 4
NM_001410275.1	NP_001397204.1	receptor-type tyrosine-protein phosphatase O isoform 5
NM_011216.4	NP_035346.3	receptor-type tyrosine-protein phosphatase O isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	20804755	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15673668	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19573017	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	15673668	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	19800005	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20398064	MGI
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	20398064	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20804755	MGI
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	15673668	MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA IDA: Inferred from direct assay	26063811	MGI
involved in podocyte differentiation	IMP IMP: Inferred from mutant phenotype	11086029	MGI
involved in regulation of glomerular filtration	IMP IMP: Inferred from mutant phenotype	11086029	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	28871037	MGI
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	28871037	MGI
involved in slit diaphragm assembly	IMP IMP: Inferred from mutant phenotype	11086029	MGI

Cellular Component GO Annotation	Evidence	Références	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	28871037	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	28871037	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20633639	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	19924828	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28871037	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28871037	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	20633639	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15673668	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	28871037	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	28871037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase O	PTPase U2 glomerular epithelial protein 1 protein tyrosine phosphatase U2 protein tyrosine phosphatase, non-receptor type 15 receptor protein tyrosine phosphatase RO

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N1966	(E)-Osmundacetone		99.81%	Unkown
HY-183573	PTPRO-IN-1	Inhibitor	/	Unkown
HY-RS11446	PTPRO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11451	PTPRU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpro	NCBI	NCBI:5800