HIC2 - HIC ZBTB transcriptional repressor 2 Gene

Also Known as HRG22; ZBTB30; ZNF907

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23119

About HIC2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,417,371-21,451,463 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 36 paralogues. Broad expression in placenta (RPKM 3.4), testis (RPKM 2.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HIC2 Products (1)

mRNA Protein Name
NM_015094.3 NP_055909.2 hypermethylated in cancer 2 protein
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12052894 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
11554746 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIC2 Protein Structure

BTB

BTB: BTB/POZ domain (36 - 141)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (447 - 464)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (505 - 527)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (533 - 555)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (576 - 599)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 615 a.a.
Protein Preferred Names Protein Names

hypermethylated in cancer 2 protein

  • HIC1-related gene on chromosome 22 protein

HIC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
HIC2 Q96JB3 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
HIC2 Q96JB3 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
Intra
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
Intra
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
Intra
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
Intra
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
Intra
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Orofaciodigital Syndrome X
  • OFD10

  • Orofaciodigital Syndrome With Fibular Aplasia

  • Oral-Facial-Digital Syndrome With Fibular Aplasia

  • Ofds X

  • Oral-Facial-Digital Syndrome, Type X

  • Orofaciodigital Syndrome 10

  • Ofd Syndrome 10

  • Ofds 10

  • Oral Facial Digital Syndrome 10

  • Oral Facial Digital Syndrome Type 10

  • Oral-Facial-Digital Syndrome 10

  • Orofaciodigital Syndrome Type Figuera

  • Orofaciodigital Syndrome Type 10

  • Figuera Syndrome

  • Oral-Facial-Digital Syndrome Type 10

Digeorge Syndrome
  • Chromosome 22q11.2 Deletion Syndrome

  • DGS

  • Hypoplasia Of Thymus And Parathyroids

  • Third And Fourth Pharyngeal Pouch Syndrome

  • 22q11.2 Deletion Syndrome

  • Digeorge Sequence

  • Digeorge'S Syndrome

  • Pharyngeal Pouch Syndrome

  • Di-George Syndrome

  • Shprintzen Syndrome

Simpson-Golabi-Behmel Syndrome, Type 1
  • Simpson-Golabi-Behmel Syndrome Type 1

  • Simpson-Golabi-Behmel Syndrome

  • SGBS1

  • Golabi-Rosen Syndrome

  • Simpson Dysmorphia Syndrome

  • Sgbs

  • Bulldog Syndrome

  • Dgsx

  • Sdys

  • Dysplasia Gigantism Syndrome, X-Linked

  • X-Linked Dysplasia Gigantism Syndrome

  • Dgsx Golabi-Rosen Syndrome

  • Sara Angers Syndrome

  • Sgb Syndrome

  • Mental Retardation-Overgrowth Syndrome

  • Simpson Dysplasia Syndrome

  • Simpson Syndrome

  • Simpson-Golabi-Behmel Syndrome 1

  • Dysplasia Gigantism Syndrome X-Linked

Van Den Ende-Gupta Syndrome
  • VDEGS

  • Blepharophimosis, Arachnodactyly, And Congenital Contractures

  • Marden-Walker-Like Syndrome

  • Marden-Walker-Like Syndrome Without Psychomotor Retardation

  • Marden Walker Like Syndrome

  • Marden-Walker-Like Syndrome Without Psychmotor Retardation

  • Van Den Ende Gupta Syndrome

  • Marden Walker Like Syndrome Without Psychomotor Retardation

  • Blepharophimosis Arachnodactyly And Congenital Contractures

Velocardiofacial Syndrome
  • Shprintzen Syndrome

  • VCFS

  • Chromosome 22q11.2 Deletion Syndrome

  • Vcf Syndrome

  • Shprintzen Vcf Syndrome

  • Vcf-Velocardiofacial Syndrome

  • Velo-Cardio-Facial Syndrome

  • Digeorge Syndrome

  • 22q11 Deletion Syndrome

  • Conotruncal Anomaly Face Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta HIC2 VGNC VGNC:82156
Bos taurus HIC2 VGNC VGNC:29846
Mus musculus HIC2 MGD MGI:1929869
Canis familiaris HIC2 VGNC VGNC:41684
Rattus norvegicus HIC2 RGD RGD:1305338
Felis catus HIC2 VGNC VGNC:62812
Others HIC2 NCBI