HIC2 - HIC ZBTB transcriptional repressor 2 Gene
Also Known as HRG22; ZBTB30; ZNF907
Species: Homo sapiens
About HIC2
This gene has 3 transcripts (splice variants), 187 orthologues and 36 paralogues. Broad expression in placenta (RPKM 3.4), testis (RPKM 2.9) and 25 other tissues.
Summary
Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
HIC2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_015094.3 | NP_055909.2 | hypermethylated in cancer 2 protein |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12052894 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11554746 | GOA |
HIC2 Protein Structure
BTB: BTB/POZ domain (36 - 141)
zf-C2H2_4: C2H2-type zinc finger (447 - 464)
zf-C2H2: Zinc finger, C2H2 type (505 - 527)
zf-C2H2: Zinc finger, C2H2 type (533 - 555)
zf-H2C2_2: Zinc-finger double domain (576 - 599)
- 0
- 100
- 200
- 300
- 400
- 500
- 615 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hypermethylated in cancer 2 protein |
|
HIC2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
HIC2 | Q96JB3 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | EHMT2 | Homo sapiens | Q96KQ7 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | EHMT2 | Homo sapiens | Q96KQ7 | 32296183 | |
|
Intra
|
HIC2 | Q96JB3 | EHMT2 | Homo sapiens | Q96KQ7 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Orofaciodigital Syndrome X |
|
|
| Digeorge Syndrome |
|
|
| Simpson-Golabi-Behmel Syndrome, Type 1 |
|
|
| Van Den Ende-Gupta Syndrome |
|
|
| Velocardiofacial Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | HIC2 | VGNC | VGNC:82156 |
| Bos taurus | HIC2 | VGNC | VGNC:29846 |
| Mus musculus | HIC2 | MGD | MGI:1929869 |
| Canis familiaris | HIC2 | VGNC | VGNC:41684 |
| Rattus norvegicus | HIC2 | RGD | RGD:1305338 |
| Felis catus | HIC2 | VGNC | VGNC:62812 |
| Others | HIC2 | NCBI |