Nt5e - 5' nucleotidase, ecto Gene

Also Known as NT; Nt5; eNT; CD73; 5'-NT; 2210401F01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23959

About Nt5e

Chromosome 9: 88,209,250-88,254,145 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 16 phenotypes. Broad expression in bladder adult (RPKM 18.6), lung adult (RPKM 11.8) and 21 other tissues.

Summary

This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. [provided by RefSeq, Sep 2016]

Nt5e Products (1)

mRNA	Protein	Name
NM_011851.4	NP_035981.1	5'-nucleotidase preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables 5'-nucleotidase activity	IDA IDA: Inferred from direct assay	8224905	MGI
enables 5'-nucleotidase activity	IMP IMP: Inferred from mutant phenotype	16547283	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in ADP catabolic process	IMP IMP: Inferred from mutant phenotype	20430891	MGI
acts upstream of or within AMP catabolic process	IMP IMP: Inferred from mutant phenotype	16547283	MGI
involved in AMP catabolic process	IMP IMP: Inferred from mutant phenotype	20430891	MGI
acts upstream of or within adenosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	16547283	MGI
involved in calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	28592560	MGI
involved in inhibition of non-skeletal tissue mineralization	IMP IMP: Inferred from mutant phenotype	25644539	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	16547283	MGI

Cellular Component GO Annotation	Evidence	Références	Source
is active in external side of plasma membrane	IMP IMP: Inferred from mutant phenotype	28746349	MGI
located in membrane	IDA IDA: Inferred from direct assay	16547283	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11375348	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nt5e Protein Structure

MPP_CD73_N

5_nucleotid_C

0
100
200
300
400
500
576 a.a.

Protein Preferred Names	Protein Names
5'-nucleotidase	ecto-5'-nucleotidase

Recombinant Nt5e Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7448	CD73/5'-Nucleotidase Protein, Mouse (HEK293, His)	Q61503 (W29-F550)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P991009	Mavrostobart		98.50%	Phase 2
HY-P991332	JAB-BX102	Inhibitor	/	Phase 2
HY-P991330	BMS-986179	Inhibitor	/	Phase 2
HY-P990771	Uprevstobart		96.98%	Phase 1
HY-P991443	IPH5301	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09612	NT5E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09613	Nt5e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09614	Nt5e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990900	Ansipastobart		96.259%	Unkown
HY-P991331	BC-010	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nt5e	NCBI	NCBI:4907