Itm2b - integral membrane protein 2B Gene

Also Known as Bri; imBRI2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 290364

Summary

Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be integral component of organelle membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Apr 2022]

Itm2b Products (1)

mRNA Protein Name
NM_001006963.1 NP_001006964.1 integral membrane protein 2B

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
29476059 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integral membrane protein 2B

  • immature BRI2

  • transmembrane protein BRI

Itm2b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Itm2b Q5XIE8 Gap43 Rattus norvegicus P07936
Anti Bait CoIP
29476059
Intra
Itm2b Q5XIE8 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
29476059
Intra
Itm2b Q5XIE8 Syp Rattus norvegicus P07825
Anti Bait CoIP
29476059
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P10192 Amyloid Bri Protein (1-23) Inhibitor / Unkown
HY-RS06984 ITM2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21603 Itm2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28121 Itm2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itm2b NCBI NCBI:9445