Amyloid Bri Protein (1-23)
Amyloid Bri Protein (1-23) (ABri peptide (1-23); ABri23) is a physiological 23-amino-acid peptide released from the C-terminus of the type II transmembrane protein Bri2 (ITM2B, Integral Membrane Protein 2B) following cleavage by the furin protease. Amyloid Bri Protein (1-23) interacts with the extracellular Brichos domain of Bri2 during Bri2 biosynthesis. Amyloid Bri Protein (1-23) interacts with amyloid β peptide (Aβ1-40, thereby inhibiting its aggregation and fibril formation. Amyloid Bri Protein (1-23) can be used in studies related to Alzheimer's disease and familial British dementia.
For research use only. We do not sell to patients.
- CAS No.: 717122-86-6
- Formula: C116H175N31O35S2
- Molecular Weight:2627.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Amyloid Bri Protein (1-23) (50 μM) is preferentially bound by purified recombinant human Bri2(90-236) (20 μM) with high affinity, forming stable 1:1 complexes under ESI-MS conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 717122-86-6
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Molecular Weight 2627.95
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Formula C116H175N31O35S2
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SMILES
O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N1)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)C)=O)CC2=CC=CC=C2)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)C(C)C)=O)C)=O)CC3=CC=CC=C3)=O)CCCCN)=O)CC(N)=O)=O)CCC(O)=O)=O)CC4=CC=CC=C4)[C@@H]1CC5=CN=CN5
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Synonyms
ABri peptide (1-23); ABri23
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Sequence
Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser (Disulfide bridge: Cys5-Cys22)
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Sequence Shortening
EASNCFAIRHFENKFAVETLICS (Disulfide bridge: Cys5-Cys22)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amyloid Bri Protein (1-23) Related Classifications
HY-P10192 Related Classifications
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