Amyloid Bri Protein (1-23)  (Synonyms: ABri peptide (1-23); ABri23)

Amyloid Bri Protein (1-23) (ABri peptide (1-23); ABri23) is a physiological 23-amino-acid peptide released from the C-terminus of the type II transmembrane protein Bri2 (ITM2B, Integral Membrane Protein 2B) following cleavage by the furin protease. Amyloid Bri Protein (1-23) interacts with the extracellular Brichos domain of Bri2 during Bri2 biosynthesis. Amyloid Bri Protein (1-23) interacts with amyloid β peptide (Aβ1-40, thereby inhibiting its aggregation and fibril formation. Amyloid Bri Protein (1-23) can be used in studies related to Alzheimer's disease and familial British dementia^[1].

Amyloid Bri Protein (1-23) (50 μM) is preferentially bound by purified recombinant human Bri2(90-236) (20 μM) with high affinity, forming stable 1:1 complexes under ESI-MS conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2627.95

C₁₁₆H₁₇₅N₃₁O₃₅S₂

717122-86-6

Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser (Disulfide bridge: Cys5-Cys22)

EASNCFAIRHFENKFAVETLICS (Disulfide bridge: Cys5-Cys22)

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N1)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)C)=O)CC2=CC=CC=C2)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)C(C)C)=O)C)=O)CC3=CC=CC=C3)=O)CCCCN)=O)CC(N)=O)=O)CCC(O)=O)=O)CC4=CC=CC=C4)[C@@H]1CC5=CN=CN5

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• [1]. Peng S, et al. The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation. Biochem Biophys Res Commun. 2010 Mar 12;393(3):356-61.