717122-86-6
Chemical Structure
Amyloid Bri Protein (1-23)
Synonym(s): ABri peptide (1-23); ABri23
- CAS No.: 717122-86-6
- Formula:C116H175N31O35S2
- Molecular Weight:2627.95
SMILES: O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N1)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)C)=O)CC2=CC=CC=C2)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)C(C)C)=O)C)=O)CC3=CC=CC=C3)=O)CCCCN)=O)CC(N)=O)=O)CCC(O)=O)=O)CC4=CC=CC=C4)[C@@H]1CC5=CN=CN5
Biological Activity: Amyloid Bri Protein (1-23) (ABri peptide (1-23); ABri23) is a physiological 23-amino-acid peptide released from the C-terminus of the type II transmembrane protein Bri2 (ITM2B, Integral Membrane Protein 2B) following cleavage by the furin protease. Amyloid Bri Protein (1-23) interacts with the extracellular Brichos domain of Bri2 during Bri2 biosynthesis. Amyloid Bri Protein (1-23) interacts with amyloid β peptide (Aβ1-40, thereby inhibiting its aggregation and fibril formation. Amyloid Bri Protein (1-23) can be used in studies related to Alzheimer's disease and familial British dementia[1].
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Amyloid Bri Protein (1-23) | Amyloid Bri Protein (1-23) (ABri peptide (1-23); ABri23) is a physiological 23-amino-acid peptide released from the C-terminus of the type II transmembrane protein Bri2 (ITM2B, Integral Membrane Protein 2B) following cleavage by the furin protease. Amyloid Bri Protein (1-23) interacts with the extracellular Brichos domain of Bri2 during Bri2 biosynthesis. Amyloid Bri Protein (1-23) interacts with amyloid β peptide (Aβ1-40, thereby inhibiting its aggregation and fibril formation. Amyloid Bri Protein (1-23) can be used in studies related to Alzheimer's disease and familial British dementia. | |||||||||||||||||||||
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