Syp - synaptophysin Gene

Also Known as Syp1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24804

Summary

Enables protein domain specific binding activity and syntaxin-1 binding activity. Involved in endocytosis; regulation of Opioid Receptor signaling pathway; and response to amyloid-beta. Located in several cellular components, including excitatory synapse; postsynaptic density; and synaptic vesicle membrane. Part of protein-containing complex. Is integral component of synaptic vesicle membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]

Syp Products (1)

mRNA Protein Name
NM_012664.3 NP_036796.1 synaptophysin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IPI
IPI: Inferred from physical interaction
19196426 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11786535 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11786535 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8567678 RGD
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
7553862 RGD
Biological Process GO Annotation Evidence References Source
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
17005904 RGD
involved in regulation of opioid receptor signaling pathway IDA
IDA: Inferred from direct assay
17005904 RGD
involved in response to amyloid-beta IEP
IEP: Inferred from expression pattern
20847448 RGD
Cellular Component GO Annotation Evidence References Source
located in excitatory synapse IDA
IDA: Inferred from direct assay
19730411 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
11786535 RGD
located in neuron spine IDA
IDA: Inferred from direct assay
20083202 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
26595655 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
17310244 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
8567678 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
10908612 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
3923488 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23792689 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
12181340 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptophysin

  • major synaptic vesicle protein p38

Syp Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Syp P07825 Itm2b Rattus norvegicus Q5XIE8
Anti Bait CoIP
29476059
Intra
Syp P07825 Oprm1 Rattus norvegicus P33535
Anti Tag CoIP
17005904
Intra
Syp P07825 Oprm1 Rattus norvegicus P33535
Y2H
17005904
Intra
Syp P07825 Oprm1 Rattus norvegicus P33535
Pull Down
17005904
Cross
Syp P07825 Srcin1 Mus musculus Q9QWI6-2
Anti Tag CoIP
18662323
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100693 SYP-5 Inhibitor 99.21% Unkown
HY-136356 Triclopyricarb Inhibitor / Unkown
HY-136915 Pyrisoxazole Inhibitor / Unkown
HY-RS14102 SYP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122480 Fenaminstrobin Inhibitor / Unkown
HY-17521 Flumorph Inhibitor 99.57% Unkown
HY-RS16733 Ptpn11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20686 Syp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27197 Syp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syp NCBI NCBI:6855