Oprm1 - opioid receptor, mu 1 Gene

Also Known as MORA; Oprm; Oprrm1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25601

Summary

Enables several functions, including G-protein beta-subunit binding activity; filamin binding activity; and morphine receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and response to alkaloid. Located in several cellular components, including dendrite; focal adhesion; and perikaryon. Is active in spine apparatus. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with sarcolemma. Biomarker of brain ischemia and human immunodeficiency virus infectious disease. Orthologous to human OPRM1 (Opioid Receptor mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Oprm1 Products (12)

mRNA Protein Name
NM_001038597.2 NP_001033686.1 mu-type opioid receptor isoform IA
NM_001038599.2 NP_001033688.2 mu-type opioid receptor isoform 1B2
NM_001038600.2 NP_001033689.1 mu-type opioid receptor isoform 1C1
NM_001038601.2 NP_001033690.1 mu-type opioid receptor isoform 1C2
NM_001304733.1 NP_001291662.1 mu-type opioid receptor isoform 1G1
NM_001304734.1 NP_001291663.1 mu-type opioid receptor isoform 1G2
NM_001304735.1 NP_001291664.1 mu-type opioid receptor isoform 1
NM_001304736.1 NP_001291665.1 mu-type opioid receptor isoform 1H2
NM_001304737.1 NP_001291666.1 mu-type opioid receptor isoform 1
NM_001304738.1 NP_001291667.1 mu-type opioid receptor isoform 1
NM_001304740.1 NP_001291669.1 mu-type opioid receptor isoform 1
NM_013071.2 NP_037203.1 mu-type opioid receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
15525342 RGD
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
9224819 RGD
enables G-protein beta-subunit binding IPI
IPI: Inferred from physical interaction
19682558 RGD
enables morphine receptor activity IDA
IDA: Inferred from direct assay
11779147 RGD
enables morphine receptor activity IMP
IMP: Inferred from mutant phenotype
9224819 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12519790 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
20214800 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
1846076 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11779147 RGD
involved in acute inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
19298846 RGD
involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
8051154 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11779147 RGD
involved in adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
IDA: Inferred from direct assay
17157995 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
15949635 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
21041644 RGD
involved in excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
18065149 RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15748148 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: Inferred from mutant phenotype
34270714 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9572309 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17384143 RGD
involved in positive regulation of appetite IMP
IMP: Inferred from mutant phenotype
18805404 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
34270714 RGD
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
17976846 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17425581 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
17156932 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
28511993 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
19301417 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
17142830 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17553897 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
32388931 RGD
involved in sperm ejaculation IDA
IDA: Inferred from direct assay
31310777 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
26686371 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17194545 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
16194531 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
16194531 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
17157995 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
26686371 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17194545 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
11312309 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
11312309 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
26686371 RGD
is active in spine apparatus IDA
IDA: Inferred from direct assay
11312309 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mu-type opioid receptor

  • M-OR-1

  • MOR-1

  • MUOR1

  • opioid receptor B

Oprm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Oprm1 P33535 Wls Rattus norvegicus Q6P689
Anti Bait CoIP
20214800
Intra
Oprm1 P33535 Gpm6a Rattus norvegicus Q812E9
Confocal
17548356
Intra
Oprm1 P33535 Gpm6a Rattus norvegicus Q812E9
Anti Tag CoIP
17548356
Intra
Oprm1 P33535 Pld2 Rattus norvegicus P70498
Anti Tag CoIP
12519790
Intra
Oprm1 P33535 Syp Rattus norvegicus P07825
Y2H
17005904
Intra
Oprm1 P33535 Syp Rattus norvegicus P07825
Confocal
17005904
Intra
Oprm1 P33535 Syp Rattus norvegicus P07825
BRET
17005904
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116163 ML350 / Unkown
HY-13906 Largazole Inhibitor / Unkown
HY-RS09806 OPRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oprm1 NCBI NCBI:4988