Gpm6a - glycoprotein m6a Gene

Also Known as M6a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306439

Summary

Enables Calcium Channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Apr 2022]

Gpm6a Products (3)

mRNA Protein Name
NM_001394533.1 NP_001381462.1 neuronal membrane glycoprotein M6-a isoform 2
NM_001394534.1 NP_001381463.1 neuronal membrane glycoprotein M6-a isoform 3
NM_178105.3 NP_835206.1 neuronal membrane glycoprotein M6-a isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
12359212 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17548356 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
21426347 RGD
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
27793698 RGD
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
27793698 RGD
involved in synapse assembly IDA
IDA: Inferred from direct assay
19737934 RGD
Cellular Component GO Annotation Evidence References Source
located in filopodium IDA
IDA: Inferred from direct assay
16286650 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10447243 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27793698 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
21426347 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21426347 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
10447243 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16286650 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
10447243 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal membrane glycoprotein M6-a

Gpm6a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gpm6a Q812E9 Oprm1 Rattus norvegicus P33535
Pull Down
17548356
Intra
Gpm6a Q812E9 Oprm1 Rattus norvegicus P33535
Anti Tag CoIP
17548356
Intra
Gpm6a Q812E9 Oprm1 Rattus norvegicus P33535
BRET
17548356
Intra
Gpm6a Q812E9 Oprm1 Rattus norvegicus P33535
Y2H
17548356
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05643 GPM6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22535 Gpm6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29055 Gpm6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpm6a NCBI NCBI:2823