WLS - Wls Wnt ligand secretion mediator Gene

Also Known as Gpr177

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362065

Summary

Enables mu-type Opioid Receptor binding activity. Predicted to be involved in several processes, including animal organ development; positive regulation of cell communication; and protein transport. Located in dendrite cytoplasm and dendrite membrane. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Apr 2022]

WLS Products (2)

mRNA Protein Name
NM_001085353.1 NP_001078822.1 protein wntless homolog
NM_199408.3 NP_955440.1 protein wntless homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mu-type opioid receptor binding IPI
IPI: Inferred from physical interaction
20214800 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20214800 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
25424568 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24333843 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
22001156 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
22001156 RGD
located in nucleus IDA
IDA: Inferred from direct assay
24333843 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
24333843 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein wntless homolog

  • EVI

  • G protein-coupled receptor 177

  • evenness interrupted homolog

  • integral membrane protein GPR177

  • protein evenness interrupted homolog

  • wntless Wnt ligand secretion mediator

WLS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Wls Q6P689 Oprm1 Rattus norvegicus P33535
Anti Bait CoIP
20214800
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15822 WLS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22087 Wls Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28607 Wls Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens WLS NCBI NCBI:79971