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Cat. No.: HY-112481

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IKK2-IN-5

IKK2-IN-5 is a selective IKK-2 inhibitor with an IC₅₀ of 0.025 μM. IKK2-IN-5 inhibits the production of TNF-α in LPS (HY-D1056)-stimulated human peripheral blood mononuclear cells. IKK2-IN-5 exhibits extremely low cytotoxicity against human peripheral blood mononuclear cells.

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CAS No.: 354810-80-3
Formule: C₁₂H₁₁N₃O₂S
Masse moléculaire:261.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IKK2-IN-5 Chemical Structure

CAS No.: 354810-80-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

IKK2-IN-5 (compound 4) (16.5 h) inhibits LPS (HY-D1056)-induced TNF-α production in human PBMCs with an IC₅₀ of 0.25 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 354810-80-3
Masse moléculaire 261.30
Formule C₁₂H₁₁N₃O₂S
SMILES

O=C(N)NC=1C=C(SC1C(=O)N)C=2C=CC=CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Baxter A, et al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004;14(11):2817-2822. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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