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Cat. No.: HY-183323

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MmpL3-IN-6

MmpL3-IN-6 is a mycobacterial membrane protein large 3 (MmpL3) transporter inhibitor and is an antitubercular agent. MmpL3-IN-6 exerts bactericidal activity against replicating Mycobacterium tuberculosis.MmpL3-IN-6 retains activity against drug-resistant Mycobacterium tuberculosis.MmpL3-IN-6 can be used for the research of tuberculosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₄H₃₃N₃OSi
Masse moléculaire:407.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MmpL3-IN-6 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

MmpL3-IN-6 (Compound 12) (7 days) inhibits Mycobacterium tuberculosis H37Rv growth with an MIC of 1.00 μM, shows moderate cytotoxicity against HepG2 cells with an IC₅₀ of 38 μM, has an aqueous solubility of 105 μM at pH 7.4, and a logD of 2.4^[1].
MmpL3-IN-6 exhibits bactericidal activity against replicating Mycobacterium tuberculosis H37Rv with an MBC₉₉ of 1.90 μM^[1].
MmpL3-IN-6 has enhanced effectiveness when Mycobacterium tuberculosis MmpL3 is silenced via CRISPRi, confirming MmpL3 as the primary target^[1].
MmpL3-IN-6 (10 μM) inhibits hERG K⁺ channel activity by 90% and does not significantly inhibit KCNQ1 K⁺ channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	CL_blood	CL_unbound
Mice^[1]	3 mg/kg	i.v.	/	77 mL/min/kg	549 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	8 %	/	/

Chemical Information

Masse moléculaire 407.62
Formule C₂₄H₃₃N₃OSi
SMILES

C[Si]1(CCN(CC1)CC2=NN(C(C3CC3)=C2)C4=CC=C(C=C4)C5=CCOCC5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Khonde LP, et al. Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitors. Eur J Med Chem. 2026;312:118841. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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