CUR61414
Based on 1 publication(s) in Google Scholar
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 334998-36-6
- Formula: C31H42N4O5
- Molecular Weight:550.69
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Stem Cell Signaling Compound Library
HY-L017
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Wnt/Hedgehog/Notch Compound Library
HY-L020
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Anti-Aging Compound Library
HY-L034
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Differentiation Inducing Compound Library
HY-L038
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Colorectal Cancer Compound Library
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Cancer Stem Cells Compound Library
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Heterocyclic Compound Library
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Highly Selective Inhibitors Library
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Highly Selective Activators Library
HY-L159
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Cell Death Library
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Anti-Hematopathy Compound Library
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Publications Citing Use of MedChemExpress (MCE) CUR61414
More
Biological Activity
Hedgehog inhibitor[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | IC50 |
0.3 μM
Compound: Cur61414
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Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assay
Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assay
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[PMID: 21592788] |
| C3H 10T1/2 | IC50 |
300 nM
Compound: Cur61414
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Inhibition of SAG-induced differentiation of mouse mesenchymal pluripotent C3H10T1/2 cells to alkaline phosphatase positive oeseoblasts after 6 hrs
Inhibition of SAG-induced differentiation of mouse mesenchymal pluripotent C3H10T1/2 cells to alkaline phosphatase positive oeseoblasts after 6 hrs
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[PMID: 22268551] |
| Shh Light II | IC50 |
0.1 μM
Compound: Cur61414
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Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay
Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay
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[PMID: 21592788] |
| Shh Light II | IC50 |
140 nM
Compound: Cur61414
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Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay
Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay
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[PMID: 22268551] |
CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 334998-36-6
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Appearance Solid
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Molecular Weight 550.69
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Formula C31H42N4O5
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Color Off-white to light yellow
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SMILES
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (181.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4. [Content Brief]
[2]. Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8159 mL | 9.0795 mL | 18.1590 mL | 45.3976 mL |
| 5 mM | 0.3632 mL | 1.8159 mL | 3.6318 mL | 9.0795 mL | |
| 10 mM | 0.1816 mL | 0.9080 mL | 1.8159 mL | 4.5398 mL | |
| 15 mM | 0.1211 mL | 0.6053 mL | 1.2106 mL | 3.0265 mL | |
| 20 mM | 0.0908 mL | 0.4540 mL | 0.9080 mL | 2.2699 mL | |
| 25 mM | 0.0726 mL | 0.3632 mL | 0.7264 mL | 1.8159 mL | |
| 30 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL | 1.5133 mL | |
| 40 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1349 mL | |
| 50 mM | 0.0363 mL | 0.1816 mL | 0.3632 mL | 0.9080 mL | |
| 60 mM | 0.0303 mL | 0.1513 mL | 0.3027 mL | 0.7566 mL | |
| 80 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5675 mL | |
| 100 mM | 0.0182 mL | 0.0908 mL | 0.1816 mL | 0.4540 mL |
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