Mcu - mitochondrial calcium uniporter Gene

Also Known as Ccdc109a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294560

Summary

Enables uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Apr 2022]

Mcu Products (1)

mRNA Protein Name
NM_001106398.1 NP_001099868.1 calcium uniporter protein, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables uniporter activity IDA
IDA: Inferred from direct assay
16920631 RGD
enables uniporter activity IMP
IMP: Inferred from mutant phenotype
22425903 RGD
Biological Process GO Annotation Evidence References Source
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
22425903 RGD
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
16920631 RGD
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22425903 RGD
involved in positive regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
16920631 RGD
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22425903 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16920631 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium uniporter protein, mitochondrial

  • coiled-coil domain containing 109A

  • coiled-coil domain-containing protein 109A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138620 MCU-i4 Inhibitor 99.87% Unkown
HY-W194810 MCU-i11 98.05% Unkown
HY-117548 UNC1062 98.92% Unkown
HY-RS08252 MCU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16775 Mcu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23215 Mcu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcu NCBI NCBI:90550