MCU - mitochondrial calcium uniporter Gene

Homo sapiens

Also known as HsMCU; C10orf42; CCDC109A

Gene ID: 90550 | Gene type: protein coding

About MCU

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,692,143-72,887,694 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 19.3), colon (RPKM 14.7) and 24 other tissues.

Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

MCU Products(3)

mRNA	Protein	Name
NM_001270679.2	NP_001257608.1	calcium uniporter protein, mitochondrial isoform 2 precursor
NM_001270680.3	NP_001257609.1	calcium uniporter protein, mitochondrial isoform 3
NM_138357.3	NP_612366.1	calcium uniporter protein, mitochondrial isoform 1 precursor

MCU Protein Structure

MCU

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

calcium uniporter protein, mitochondrial

coiled-coil domain-containing protein 109A

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Ischemia

Acute Coronary Syndrome

Myopathy With Extrapyramidal Signs

Proximal Myopathy With Extrapyramidal Signs	MPXPS
Myopathy, With Extrapyramidal Signs

Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary	Malignant Ovarian Endometrioid Tumor
Ovarian Endometrioid Neoplasm

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138620	MCU-i4	Inhibitor	99.87%	Unkown
HY-RS08252	MCU Human Pre-designed siRNA Set A		/	Unkown
HY-W194810	MCU-i11		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MCU	VGNC	VGNC:63421
Rattus norvegicus	MCU	RGD	RGD:1589771
Mus musculus	MCU	MGD	MGI:3026965
Macaca mulatta	MCU	VGNC	VGNC:74560
Canis familiaris	MCU	VGNC	VGNC:43096
Bos taurus	MCU	VGNC	VGNC:31325
Others	MCU	NCBI

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