MCU - mitochondrial calcium uniporter Gene

Also Known as HsMCU; C10orf42; CCDC109A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90550

About MCU

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,692,143-72,887,694 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 19.3), colon (RPKM 14.7) and 24 other tissues.

Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

MCU Products (3)

mRNA Protein Name
NM_001270679.2 NP_001257608.1 calcium uniporter protein, mitochondrial isoform 2 precursor
NM_001270680.3 NP_001257609.1 calcium uniporter protein, mitochondrial isoform 3
NM_138357.3 NP_612366.1 calcium uniporter protein, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
21685888 GOA
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
23755363 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21685886 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21685886 GOA
enables uniporter activity IDA
IDA: Inferred from direct assay
21685886 GOA
enables uniporter activity IMP
IMP: Inferred from mutant phenotype
23755363 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
22925203 GOA
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
23755363 GOA
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
21685886 GOA
involved in cellular response to calcium ion starvation IMP
IMP: Inferred from mutant phenotype
32494073 GOA
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22829870 GOA
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
21685888 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21685886 GOA
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22829870 GOA
involved in positive regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
21685888 GOA
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
21685886 GOA
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
28388446 GOA
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
28388446 GOA
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
21685886 GOA
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
23755363 GOA
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
31080062 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
21685886 GOA
part of uniplex complex IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IPI
IPI: Inferred from physical interaction
32494073 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCU Protein Structure

MCU

MCU: Mitochondrial calcium uniporter (109 - 321)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

calcium uniporter protein, mitochondrial

  • coiled-coil domain-containing protein 109A

MCU Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MCU Q8NE86 SMDT1 Homo sapiens Q9H4I9
Anti Tag CoIP
32494073
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
26387864
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
IF
26387864
Intra
MCU Q8NE86 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
32494073
Cross: Cross-species interaction Intra: Intraspecies interaction

MCU Antibodies

Cat. No. Product Name Application Reactivity
HY-P80216 MCU Antibody (YA704) WB, IHC-P, ICC/IF Human, Mouse, Rat, Monkey
HY-P810766 MCU Antibody (YA10009) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P810767 Phospho-MCU (Ser92) Antibody (YA10010) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Ischemia

  • Acute Coronary Syndrome
Myopathy With Extrapyramidal Signs

  • Proximal Myopathy With Extrapyramidal Signs

  • MPXPS

  • Myopathy, With Extrapyramidal Signs
Ovarian Endometrial Cancer

  • Endometrioid Neoplasm Of Ovary

  • Malignant Ovarian Endometrioid Tumor

  • Ovarian Endometrioid Neoplasm
Spinocerebellar Ataxia 28

  • Spinocerebellar Ataxia Type 28

  • SCA28

  • Ataxia, Spinocerebellar, Type 28
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138620 MCU-i4 Inhibitor 99.94% Unkown
HY-W194810 MCU-i11 98.05% Unkown
HY-117548 UNC1062 98.92% Unkown
HY-RS08252 MCU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16775 Mcu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23215 Mcu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MCU VGNC VGNC:63421
Rattus norvegicus MCU RGD RGD:1589771
Mus musculus MCU MGD MGI:3026965
Macaca mulatta MCU VGNC VGNC:74560
Canis familiaris MCU VGNC VGNC:43096
Bos taurus MCU VGNC VGNC:31325
Others MCU NCBI