MEIS2 - Meis homeobox 2 Gene

Also Known as MRG1; CPCMR; HsT18361

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4212

About MEIS2

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:36,889,204-37,101,311 (from NCBI)

This gene has 38 transcripts (splice variants), 289 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 12.8), prostate (RPKM 12.0) and 24 other tissues.

Summary

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

MEIS2 Products (8)

mRNA	Protein	Name
NM_001220482.2	NP_001207411.1	homeobox protein Meis2 isoform d
NM_002399.4	NP_002390.1	homeobox protein Meis2 isoform f
NM_170674.5	NP_733774.1	homeobox protein Meis2 isoform b
NM_170675.5	NP_733775.1	homeobox protein Meis2 isoform c
NM_170676.5	NP_733776.1	homeobox protein Meis2 isoform d
NM_170677.5	NP_733777.1	homeobox protein Meis2 isoform a
NM_172315.3	NP_758526.1	homeobox protein Meis2 isoform g
NM_172316.3	NP_758527.1	homeobox protein Meis2 isoform h

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	26550823	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10764806	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10764806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19559479	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17178831	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cardiac muscle myoblast proliferation	IDA IDA: Inferred from direct assay	26512644	GOA
involved in positive regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	26512644	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10764806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEIS2 Protein Structure

Homeobox_KN

0
100
200
300
400
477 a.a.

Protein Preferred Names	Protein Names
homeobox protein Meis2	Meis homolog 2

MEIS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MEIS2	O14770	CCDC196	Homo sapiens	A0A1B0GWI1	Validated Y2H	25416956
Intra	MEIS2	O14770	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	25416956
Intra	MEIS2	O14770	ANXA1	Homo sapiens	Q5TZZ9	Validated Y2H	25416956
Intra	MEIS2	O14770	ANXA1	Homo sapiens	Q5TZZ9	Y2H Array	25416956
Intra	MEIS2	O14770	PBX1	Homo sapiens	P40424	Y2H Array	20211142
Intra	MEIS2	O14770	PBX1	Homo sapiens	P40424	Anti Tag CoIP	33961781
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	25416956
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	31515488
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
Intra	MEIS2	O14770	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	Y2H Array	22458338
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	MAPPIT	22458338
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

MEIS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810763	MEIS2 Antibody (YA10006)	WB, ICC/IF	Human, Mouse, Rat
HY-P82033	MEIS2 Antibody (YA1778)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cleft Palate, Cardiac Defects, And Mental Retardation	Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies CPCMR Cleft Palate, Cardiac Defects, And Intellectual Disabillity Cleft Palate, Cardiac Defects, And Intellectual Disability Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies
Chromosome 15q14 Deletion Syndrome	15q14 Microdeletion Syndrome Del(15)(Q14) Monosomy 15q14
Cleft Palate, Cardiac Defects, And Intellectual Disability
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay	CAKUTHED Doid:0112359 Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Epilepsy, Familial Temporal Lobe, 4	ETL4 Epilepsy, Occipitotemporal Lobe, And Migraine With Aura Epolm Familial Temporal Lobe Epilepsy 4 Occipitotemporal Lobe Epilepsy And Migraine With Aura
Anemia, Congenital Dyserythropoietic, Type Ib	CDAN1B Congenital Dyserythropoietic Anemia Type Ib Cda, Type Ib Congenital Dyserythropoietic Anemia Type Type 1b Dyserythropoietic Anemia, Congenital, Type Ib Anemia, Congenital Dyserythropoietic, 1b Cda Ib Anemia, Dyserythropoietic, Congenital Anemia, Dyserythropoietic, Congenital, Type Ib
Breast Lipoma	Lipoma Of Breast
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Axenfeld-Rieger Syndrome	Axenfeld Syndrome Rieger Syndrome Rieger Anomaly Axenfeld Anomaly Anomaly, Rieger'S Hagedoom Syndrome Rgs - Rieger Syndrome Rieger'S Anomaly Goniodysgenesis Hypodontia Iridogoniodysgenesis With Somatic Anomalies Ars Axenfeld And Rieger Anomaly Axra Axrs Rieger Eye Malformation Sequence
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Orofacial Cleft	Cleft, Orofacial
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134258	MEISi-1	Inhibitor	98.16%	Unkown
HY-RS08326	MEIS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22635	Meis2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29150	Meis2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEIS2	RGD	RGD:1305198
Mus musculus	MEIS2	MGD	MGI:108564
Macaca mulatta	MEIS2	VGNC	VGNC:74702
Bos taurus	MEIS2	VGNC	VGNC:31382
Felis catus	MEIS2	VGNC	VGNC:80914
Canis familiaris	MEIS2	VGNC	VGNC:43154
Others	MEIS2	NCBI