MEIS2 Antibody (YA1778)
(Synonyms: Meis homeobox 2; Meis1 related gene 1; MEIS2; MGC2820; MRG1)MEIS2 Antibody (YA1778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEIS2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
MEIS2 Antibody (YA1778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEIS2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52 kDa
Entrez Gene: 4212 Human ; 17536 Mouse ; 311311 Rat
SwissProt: O14770 Human ; P97367 Mouse ;
OMIM: 600987 Human
A synthesized peptide derived from human MEIS2 aa1-57/477.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MEIS2 is involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription
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Subcellular Localization
Nucleus; Cytoplasm, perinuclear region
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Expression
Tissue_specificity:Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen -
Isoforms & Post-Translational Modification
O14770 has 8 isomers: O14770-1: 51790 Da (predicted); O14770-2: 43791 Da (predicted); O14770-3: 43061 Da (predicted); O14770-4: 51060 Da (predicted); O14770-5: 32837 Da (predicted); O14770-6: 33598 Da (predicted); O14770-7: 41542 Da (predicted); O14770-8: 42272 Da (predicted).
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Subunit
Monomer and homodimer (PubMed:26550823). Heterodimer with HOXB13 (Ref.16). Isoform 2 interacts with TLX1. Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3
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SwissProt ID
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Synonyms
Meis homeobox 2; Meis1 related gene 1; MEIS2; MGC2820; MRG1
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Research Field
Neuroscience
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