MEIS2 Antibody (YA10006)
(Synonyms: MRG1, MEIS2, Homeobox protein Meis2, Meis1-related protein 1)MEIS2 Antibody (YA10006) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to MEIS2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
MEIS2 Antibody (YA10006) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to MEIS2.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Synthetic peptide corresponding to human MEIS2 protein.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MEIS2 is involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription
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Subcellular Localization
Nucleus; Cytoplasm, perinuclear region
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Expression
Tissue_Specificity: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen. -
Isoforms & Post-Translational Modification
MEIS2 has 8 isoforms, O14770-1: amino acid length is 477, molecular weight is 51790 Da (predicted); O14770-2: amino acid length is 401, molecular weight is 43791 Da (predicted); O14770-3: amino acid length is 394, molecular weight is 43061 Da (predicted); O14770-4: amino acid length is 470, molecular weight is 51060 Da (predicted); O14770-5: amino acid length is 302, molecular weight is 32837 Da (predicted); O14770-6: amino acid length is 306, molecular weight is 33598 Da (predicted); O14770-7: amino acid length is 381, molecular weight is 41542 Da (predicted); O14770-8: amino acid length is 388, molecular weight is 42272 Da (predicted).
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Subunit
Monomer and homodimer.
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SwissProt ID
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Synonyms
MRG1, MEIS2, Homeobox protein Meis2, Meis1-related protein 1
Documentation
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