RPS6KA6 - ribosomal protein S6 kinase A6 Gene

Also Known as RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27330

About RPS6KA6

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:84,058,346-84,188,499 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 7 paralogues. Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues.

Summary

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from Other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

RPS6KA6 Products (10)

mRNA Protein Name
XM_017029424.2 XP_016884913.1 ribosomal protein S6 kinase alpha-6 isoform X1
XM_011530919.3 XP_011529221.1 ribosomal protein S6 kinase alpha-6 isoform X4
XM_011530920.3 XP_011529222.1 ribosomal protein S6 kinase alpha-6 isoform X5
XM_011530917.3 XP_011529219.1 ribosomal protein S6 kinase alpha-6 isoform X2
XM_017029423.2 XP_016884912.1 ribosomal protein S6 kinase alpha-6 isoform X1
NM_001330512.1 NP_001317441.1 ribosomal protein S6 kinase alpha-6 isoform 1
XM_047441997.1 XP_047297953.1 ribosomal protein S6 kinase alpha-6 isoform X3
XM_017029425.2 XP_016884914.1 ribosomal protein S6 kinase alpha-6 isoform X1
NM_014496.5 NP_055311.1 ribosomal protein S6 kinase alpha-6 isoform 2
XM_047441996.1 XP_047297952.1 ribosomal protein S6 kinase alpha-6 isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
15042092 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (73 - 330)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (354 - 393)

Pkinase

Pkinase: Protein kinase domain (426 - 683)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-6

  • 90 kDa ribosomal protein S6 kinase 6

  • S6K-alpha 6

  • p90-RSK 6

  • ribosomal S6 kinase 4

  • ribosomal protein S6 kinase, 90kDa, polypeptide 6

RPS6KA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS6KA6 Q9UK32 SPRED2 Homo sapiens Q7Z698
Y2H Array
32296183
Intra
RPS6KA6 Q9UK32 SPRED2 Homo sapiens Q7Z698
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6KA6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80851 Phospho-RSK4 (Ser232) Antibody (YA155) WB, ICC/IF Human
HY-P80851A Phospho-RSK4 (Ser232) Antibody (YA155)(PBS only) WB, ICC/IF Human

Related Diseases

Diseases Alias
X-Linked Nonsyndromic Deafness

  • X-Linked Deafness

  • Deafness, X-Linked
Papillary Cystadenocarcinoma

  • Cystadenocarcinoma, Papillary
Adrenal Cortical Adenocarcinoma

  • Adrenal Cortex Adenocarcinoma

  • Adrenocortical Carcinoma
Coffin-Lowry Syndrome

  • CLS

  • Mental Retardation With Osteocartilaginous Abnormalities

  • Coffin Syndrome 1

  • Coffin Syndrome

  • Dwarfism, Lean Spastic Type

  • Lean Spastic Dwarfism

  • Coffin Lowry Syndrome
Non-Syndromic X-Linked Intellectual Disability 77

  • Mrx77
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12259 RPS6KA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12260 Rps6ka6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12261 Rps6ka6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPS6KA6 VGNC VGNC:34145
Macaca mulatta RPS6KA6 VGNC VGNC:76932
Mus musculus RPS6KA6 MGD MGI:1914321
Rattus norvegicus RPS6KA6 RGD RGD:1560817
Canis familiaris RPS6KA6 VGNC VGNC:45743
Felis catus RPS6KA6 VGNC VGNC:64759
Others RPS6KA6 NCBI