MYH10 - myosin heavy chain 10 Gene

Also Known as NMMHCB; NMMHC-IIB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4628

About MYH10

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,474,212-8,631,345 (from NCBI)

This gene has 32 transcripts (splice variants), 212 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues.

Summary

This gene encodes a member of the Myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYH10 Products (4)

mRNA	Protein	Name
NM_001256012.3	NP_001242941.1	myosin-10 isoform 1
NM_001256095.2	NP_001243024.1	myosin-10 isoform 3
NM_001375266.1	NP_001362195.1	myosin-10 isoform 4
NM_005964.5	NP_005955.3	myosin-10 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables ADP binding	IDA IDA: Inferred from direct assay	15845534	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	15845534	GOA
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	15845534	GOA
contributes to actin filament binding	IMP IMP: Inferred from mutant phenotype	24072716	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables microfilament motor activity	IDA IDA: Inferred from direct assay	15845534	GOA
contributes to microfilament motor activity	IMP IMP: Inferred from mutant phenotype	24072716	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7542763	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within actin filament-based movement	IDA IDA: Inferred from direct assay	15845534	GOA
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	24072716	GOA
acts upstream of or within mitotic cytokinesis	IDA IDA: Inferred from direct assay	15774463	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	20603131	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in actomyosin	IDA IDA: Inferred from direct assay	24072716	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	7699007	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	7699007	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	7699007	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	20603131	GOA
located in midbody	IDA IDA: Inferred from direct assay	11029059	GOA
part of myosin II complex	IDA IDA: Inferred from direct assay	24072716	GOA
located in myosin II filament	IDA IDA: Inferred from direct assay	24072716	GOA
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	30123108	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	7699007	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYH10 Protein Structure

Myosin_N

Myosin_head

Myosin_tail_1

0
400
800
1200
1600
1976 a.a.

Protein Preferred Names	Protein Names
myosin-10	myosin heavy chain, nonmuscle type B

MYH10 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83369	MYH10 Antibody (YA3114)	WB, IP	Human, Mouse
HY-P83369A	MYH10 Antibody (YA3114)(PBS only)	WB, IP	Human, Mouse

Related Diseases

Diseases	Alias
Congenital Ptosis	Congenital Blepharoptosis Congenital Eyelid Ptosis
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Hypertelorism	Eyes Wide Apart Eyes Widely Set Hypertelorism Of Orbit Ocular Hypertelorism Orbital Separation Excessive
Myh-9 Related Disease	Myh9-Related Disease Myh9-Rd Myh9-Related Disorder Myh9-Related Syndrome Myh9-Related Syndromic Thrombocytopenia Sebastian Syndrome
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Deafness, Autosomal Dominant 17	DFNA17 Autosomal Dominant Nonsyndromic Deafness 17 Deafness, Autosomal Dominant Nonsyndromic Sensorineural 17 Autosomal Dominant Deafness 17 Late-Onset Progressive Hereditary Hearing Impairment Due To Cochleosaccular Degeneration Nonsyndromic Hereditary Deafness Dfna17 Deafness, Autosomal Dominant, 17 Cochleosaccular Degeneration Deafness, Autosomal Dominant, Type 17 Cochleosaccular Degeneration Of The Inner Ear And Progressive Cataracts
Infantile Myofibromatosis	Lipofibromatosis Myofibromatosis
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08896	MYH10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22660	Myh10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29174	Myh10 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYH10	VGNC	VGNC:43535
Felis catus	MYH10	VGNC	VGNC:68379
Bos taurus	MYH10	VGNC	VGNC:31794
Rattus norvegicus	MYH10	RGD	RGD:71000
Macaca mulatta	MYH10	VGNC	VGNC:99175
Mus musculus	MYH10	MGD	MGI:1930780
Others	MYH10	NCBI