Nr5a2 - nuclear receptor subfamily 5, group A, member 2 Gene

Also Known as Ftf; LRH-1; UF2-H3B; D1Ertd308e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26424

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; Cholesterol homeostasis; and pancreas morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and gonad. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr5a2 Products (2)

mRNA	Protein	Name
NM_001159769.2	NP_001153241.1	nuclear receptor subfamily 5 group A member 2 isoform 2
NM_030676.3	NP_109601.1	nuclear receptor subfamily 5 group A member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15014077	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12456679	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12456679	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19389484	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within acinar cell differentiation	IMP IMP: Inferred from mutant phenotype	25063451	MGI
acts upstream of or within bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	15014077	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	15014077	MGI
acts upstream of or within pancreas morphogenesis	IMP IMP: Inferred from mutant phenotype	25063451	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	30555544	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22977234	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12456679	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19389484	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15831456	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20937355	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15684064	MGI

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19389484	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor subfamily 5 group A member 2	fetoprotein transcription factor liver receptor homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-115613	ML-180	Inhibitor	99.96%	Unkown
HY-131445	RJW100	Activator	99.93%	Unkown
HY-147105	LRH-1 agonist-2		98.58%	Unkown
HY-110329	ML179	Agonist	99.73%	Unkown
HY-RS09554	NR5A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17146	Nr5a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23595	Nr5a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr5a2	NCBI	NCBI:2494