NR5A2 - nuclear receptor subfamily 5 group A member 2 Gene

Also Known as B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2494

About NR5A2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,027,710-200,177,415 (from NCBI)

This gene has 6 transcripts (splice variants), 231 orthologues and 1 paralogue. Biased expression in liver (RPKM 6.4), small intestine (RPKM 5.8) and 13 other tissues.

Summary

The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and Cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]

NR5A2 Products (3)

mRNA	Protein	Name
NM_001276464.2	NP_001263393.1	nuclear receptor subfamily 5 group A member 2 isoform 3
NM_003822.5	NP_003813.1	nuclear receptor subfamily 5 group A member 2 isoform 2
NM_205860.3	NP_995582.1	nuclear receptor subfamily 5 group A member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16289203	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15205472	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	15205472	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	15723037	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12040021	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16289203	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15205472	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701856	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15143342	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15205472	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	19264593	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15723037	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15205472	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15143342	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR5A2 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
541 a.a.

Protein Preferred Names	Protein Names
nuclear receptor subfamily 5 group A member 2	CYP7A promoter-binding factor

NR5A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR5A2	O00482	EDF1	Homo sapiens	O60869	Anti Tag CoIP	12040021

Cross: Cross-species interaction Intra: Intraspecies interaction

NR5A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82727	NR5A2 Antibody (YA2472)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Transvestism	Dual-Role Transvestism Fetishistic Transvestism Cross Dresser Transvestic Fetishism
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Fetishism	Fetishism, Psychiatric
46,Xy Sex Reversal 2	Dosage-Sensitive Sex Reversal Dss SRXY2 46,Xy Sex Reversal, Dax1-Related 46xy Sex Reversal 2, Dosage-Sensitive 46,Xy Sex Reversal Dax1-Related
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Idiopathic Peripheral Autonomic Neuropathy
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115613	ML-180	Inhibitor	99.96%	Unkown
HY-131445	RJW100	Activator	99.93%	Unkown
HY-147105	LRH-1 agonist-2		98.58%	Unkown
HY-110329	ML179	Agonist	99.73%	Unkown
HY-RS09554	NR5A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17146	Nr5a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23595	Nr5a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NR5A2	MGD	MGI:1346834
Bos taurus	NR5A2	VGNC	VGNC:32249
Canis familiaris	NR5A2	VGNC	VGNC:43956
Felis catus	NR5A2	VGNC	VGNC:97535
Macaca mulatta	NR5A2	VGNC	VGNC:75521
Rattus norvegicus	NR5A2	RGD	RGD:68353
Others	NR5A2	NCBI