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SLC35B1 - solute carrier family 35 member B1 Gene

Also Known as AXER; UGTREL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10237

About SLC35B1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,700,943-49,708,197 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.3), duodenum (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

SLC35B1 Products (2)

mRNA	Protein	Name
NM_001278784.2	NP_001265713.1	solute carrier family 35 member B1 isoform 2
NM_005827.4	NP_005818.3	solute carrier family 35 member B1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP:ADP antiporter activity	IDA IDA: Inferred from direct assay	30154480	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30154480	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35B1 Protein Structure

UAA

0
100
200
300
322 a.a.

Protein Preferred Names	Protein Names
solute carrier family 35 member B1	ATP/ADP exchanger ER

SLC35B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC35B1	P78383	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	SLC35B1	P78383	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	SLC35B1	P78383	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SLC35B1	P78383	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	SLC35B1	P78383	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	SLC35B1	P78383	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	SLC35B1	P78383	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	SLC35B1	P78383	PTPN5	Homo sapiens	P54829	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	PTPN5	Homo sapiens	P54829	Y2H Array	32296183
Intra	SLC35B1	P78383	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	SLC35B1	P78383	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SLC35B1	P78383	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC35B1	P78383	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SLC35B1	P78383	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC35B1	P78383	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	FZD5	Homo sapiens	Q13467	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	FZD5	Homo sapiens	Q13467	Validated Y2H	32296183
Intra	SLC35B1	P78383	FZD5	Homo sapiens	Q13467	Y2H Array	32296183
Intra	SLC35B1	P78383	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SLC35B1	P78383	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SLC35B1	P78383	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	SLC35B1	P78383	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	SLC35B1	P78383	FKBP8	Homo sapiens	Q14318	Validated Y2H	32296183
Intra	SLC35B1	P78383	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	SLC35B1	P78383	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	SLC35B1	P78383	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	SLC35B1	P78383	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC35B1	P78383	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	CCDC107	Homo sapiens	Q8WV48	Y2H Prey Pooling	32296183
Intra	SLC35B1	P78383	CCDC107	Homo sapiens	Q8WV48	Validated Y2H	32296183
Intra	SLC35B1	P78383	CCDC107	Homo sapiens	Q8WV48	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Barre-Lieou Syndrome	Cervicocranial Syndrome Posterior Cervical Sympathetic Syndrome
Dicarboxylic Aminoaciduria	Glutamate-Aspartate Transport Defect Dicarboxylicaminoaciduria DCBXA Renal Aminoacidurias
Bardet-Biedl Syndrome 10	BBS10 Bardet-Biedl Syndrome Bbs Bardet-Biedl Syndrome, Type 10
Hydranencephaly	Hydroanencephaly
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb	Chromosome 1q21.1 Deletion Syndrome 1q21.1 Microdeletion Syndrome Monosomy 1q21.1 1q21.1 Microdeletion Chromosome 1q21.1 Microdeletion Syndrome 1q21.1 Contiguous Gene Deletion 1q21.1 Deletion Del(1)(Q21) 1q21.1 Deletion Syndrome
Retinitis Pigmentosa 12	RP12 Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium Rp With Or Without Pprpe Retinitis Pigmentosa-12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13198	SLC35B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22040	Slc35b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC35B1	MGD	MGI:1343133
Rattus norvegicus	SLC35B1	RGD	RGD:727783
Macaca mulatta	SLC35B1	VGNC	VGNC:77533
Canis familiaris	SLC35B1	VGNC	VGNC:46364
Bos taurus	SLC35B1	VGNC	VGNC:34823
Felis catus	SLC35B1	VGNC	VGNC:65324
Others	SLC35B1	NCBI