Thionisoxetine
Thionisoxetine is a norepinephrine transporter inhibitor with a Ki value of 0.2 nM in rats, and exhibits anti-hyperalgesic and analgesic activities. Thionisoxetine reverses thermal hyperalgesia and mechanical allodynia in rats. Thionisoxetine can be used in studies related to persistent inflammatory pain.
For research use only. We do not sell to patients.
- CAS No.: 155273-01-1
- Formula: C17H21NOS
- Molecular Weight:287.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 70-90 g, inflammatory pain model induced by s.c. λ-carrageenan injection)[1]
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Dosage:0.03, 0.1, 0.3, 1, 3, 10 mg/kg; 0.01, 0.03, 0.1, 0.3, 1, 3, 10 mg/kg (co-administered with 10 mg/kg fluoxetine i.p.)
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Administration:i.p.; single dose
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Result:Produced a complete, dose-dependent reversal of carrageenan-induced thermal hyperalgesia, significant at doses of 0.3, 1, 3, and 10 mg/kg.
Produced a greater than 80% reversal of carrageenan-induced mechanical allodynia, significant at doses of 3 and 10 mg/kg.
Produced a significant leftward shift in relative potency for reversing carrageenan-induced thermal hyperalgesia.
Produced a significant leftward shift in relative potency for reversing carrageenan-induced mechanical allodynia.
Increased brain concentrations of thionisoxetine 1.09- to 5.1-fold, with analgesic potentiation exceeding pharmacokinetic changes alone, confirming pharmacodynamic synergism.
Chemical Information
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CAS No. 155273-01-1
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Molecular Weight 287.42
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Formula C17H21NOS
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SMILES
O(C=1C=CC=CC1SC)C(C=2C=CC=CC2)CCNC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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