Enfortumab vedotin-ejfv
Based on 1 publication(s) in Google Scholar
Enfortumab vedotin-ejfv is an anti-Nectin-4 antibody-drug conjugate. Enfortumab vedotin-ejfv is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable Val-Cit linker. The antibody portion is Enfortumab (HY-P99016), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma.
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- Pureza: 99.69%
- No. CAS: 1346452-25-2
- Peso molecular:152000 (average)
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Almacenamiento:
-80°C, protect from light
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Enfortumab vedotin-ejfv
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Actividad biológica
Enfortumab vedotin-ejfv is a humanized, monoclonal ADC that binds to a protein expressed on the surface of cancer cells, Nectin-4. When Enfortumab vedotin-ejfv binds to Nectin-4 on cells, it is internalized into the cell which allows proteases to break down the linker and MMAE is released. MMAE impairs the microtubule network within the cell, blocking mitosis and subsequently leading to cell death[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1346452-25-2
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Appearance Solid
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Peso molecular 152000 (average)
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Color White to off-white
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SMILES
[Enfortumab vedotin-ejfv]
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Envío
Shipping with dry ice.
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Almacenamiento
-80°C, protect from light
Publications (1)
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Journal Impact Factor
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Most Recent
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Halford Z, et al. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. Ann Pharmacother. 2021 Jun;55(6):772-782. [Content Brief]
[2]. Mantia CM, et al. Enfortumab vedotin-ejfv for the treatment of advanced urothelial carcinoma. Expert Rev Anticancer Ther. 2022;22(5):449-455. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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