Factor B-IN-5
Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy.
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- No. CAS: 1644670-23-4
- Fòrmula: C24H28N2O3
- Peso molecular:392.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male diabetic db/db C57BL/6J mice (C57BL/6J-LepRdb/db) (6 weeks)[1]
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Dosage:20 and 60 mg/kg
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Administration:Oral gavage (i.g.); twice daily for 10 weeks
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Result:Significantly reduced the level of uACR.
Significantly improved renal tubulointerstitial fibrosis and atrophy.
Significantly reduced the thickness of glomerular basement membrane (GBM).
Reduced the expression of inflammatory markers Kim-1 and IL-1β.
Improved mitochondrial morphology and dynamics and upregulated the expression of Mfn2 and Prkn.
Might exert its effect by regulating CASP3 and DPP4.
Chemical Information
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No. CAS 1644670-23-4
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Peso molecular 392.49
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Fòrmula C24H28N2O3
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SMILES
CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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